外周血miR-146a、Chemerin、TGF-β1与寻常型银屑病中医证型的相关性研究  

Study on correlation between miR-146a,Chemerin,TGF-β1in peripheral blood and TCM syndrome type of psoriasis vulgaris

作　　者：赵亮[1] 东春妮 王玮 ZHAO Liang;DONG Chunni;WANG Wei(Department of Dermatology,Xi'an Electric Power Center Hospital,Xi’an,Shaanxi 710032,China;Department of Dermatology,Huazhou Traditional Chinese Medicine Hospital,Weinan,Shaanxi 714100,China)

机构地区：[1]西安电力中心医院皮肤科,陕西西安710032 [2]华州区中医医院皮肤科,陕西渭南714100

出　　处：《四川中医》2025年第2期164-167,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探究外周血miR-146a、趋化素(Chemerin)、转化生长因子-β1(TGF-β1)与寻常型银屑病中医证型的相关性。方法:回顾性选取2022年1月~2023年12月我院诊治的寻常型银屑病患者134例,对寻常型银屑病患者进行中医证型辨证,收集并比较不同中医证型患者的临床资料、外周血miR-146a、Chemerin、TGF-β1水平、不同严重程度患者的外周血miR-146a、Chemerin、TGF-β1水平,并采用Pearson相关性分析PASI评分与其外周血miR-146a、Chemerin、TGF-β1水平的相关性。结果:134例寻常型银屑病患者中,血热证42例,占比31.34%,血瘀证47例,占比35.07%,血燥证45例,占比33.58%。各组的PASI评分呈血热组>血瘀组>血燥组,差异有统计学意义(P<0.05)。血热组的miR-146a mRNA相对表达量、Chemerin、TGF-β1水平均高于血瘀组和血燥组,血瘀组的miR-146a mRNA相对表达量、Chemerin、TGF-β1水平均高于血燥组,差异有统计学意义(P<0.05)。不同严重程度患者的外周血miR-146a mRNA相对表达量、Chemerin、TGF-β1水平均呈轻度<中度<重度,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,外周血miR-146a mRNA相对表达量、Chemerin、TGF-β1水平与PASI评分呈正相关性,差异有统计学意义(P<0.05)。结论:外周血miR-146a、Chemerin、TGF-β1在不同寻常型银屑病中医证型中的水平存在差异,且与寻常型银屑病中医证型具有正相关性。Objective:To explore the correlation between miR-146a,Chemerin,transforming growth factor-β1(TGF-β1)and traditional Chinese medicine syndrome of psoriasis vulgaris in peripheral blood.Methods:A total of 134patients with psoriasis vulgaris treated to our hospital from January 2022to December 2023were retrospectively selected.TCM syndrome differentiation was performed for psoriasis vulgaris patients.Clinical data,levels of miR-146a,Chemerin and TGF-β1in peripheral blood of patients with different TCM syndrome types,and levels of miR-146a,Chemerin and TGF-β1in peripheral blood of patients with different severity were collected and compared.Pearson correlation was used to analyze the correlation between PASI score and the levels of miR-146a,Chemerin and TGF-β1in peripheral blood.Results:Among 134patients with psoriasis vulgaris,there were 42cases of blood heat syndrome(31.34%),47cases of blood stasis syndrome(35.07%)and 45cases of blood dryness syndrome(33.58%).The PASI scores of all groups were blood heat grouP>blood stasis grouP>blood dryness group,and the difference was statistically significant(P<0.05).The relative expression level of miR-146a mRNA,Chemerin and TGF-β1in blood heat group were higher than those in blood stasis group and blood dryness group,and the relative expression level of miR-146a mRNA,Chemerin and TGF-β1in blood stasis group were higher than those in blood dryness group,with statistical significance(P<0.05).The relative expression level of miR-146a mRNA,Chemerin and TGF-β1in peripheral blood of patients with different severity were mild<moderate<severe,and the differences were statistically significant(P<0.05).The results of Pearson correlation analysis showed that the relative expression level of miR-146a mRNA,Chemerin and TGF-β1levels in peripheral blood were positively correlated with PASI scores,with statistical significance(P<0.05).Conclusion:The levels of miR-146a,Chemerin and TGF-β1in peripheral blood were different in psoriasis vulgaris,and had a positive correlation with pso

关 键 词：MIR-146A 趋化素 转化生长因子-Β1 寻常型银屑病 中医证型 

分 类 号：R275.9[医药卫生—中西医结合]