清热除湿方辅助咪唑斯汀治疗湿疹疗效及对湿疹面积、瘙痒评分和复发的影响  

Efficacy of Qingre Chushi decoction supplemented with mizolastine on eczema and its influence on eczema area,pruritus score and recurrence

作　　者：陈肖 吴静 王武浩 CHEN Xiao;WU Jing;WANG Wu Hao(Guangzhou University of Traditional Chinese Medicine Shenzhen Hospital(Futian)Dermatology Department,Shenzhen,Guangdong 518034,China)

机构地区：[1]广州中医药大学深圳医院(福田)皮肤科,广东深圳518034

出　　处：《四川中医》2025年第2期168-171,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：深圳市福田区卫生公益性科研项目(编号:FTWS2017030)。

摘　　要：目的:探究清热除湿方辅助咪唑斯汀治疗湿疹疗效及对湿疹面积、瘙痒评分和复发的影响。方法:选取我院2022年4月~2023年1月收治的80例急性期湿疹患者为研究对象。按照随机数字表将其分为对照组与观察组,各40例,对照组采用咪唑斯汀治疗,观察组采用清热除湿方辅助咪唑斯汀治疗,均治疗28d。比较两组治疗后临床疗效、症状改善情况,治疗前后症状评分[湿疹面积和严重程度指数(EASI)、视觉模拟评分法(VAS)]、炎症指标[CC型趋化因子(CCL)27、胸腺基质淋巴生成素(TSLP)],分析两组复发情况。结果:观察组临床总有效率高于对照组,各项症状改善时间均低于对照组(P<0.05);治疗28d后,两组EASI、VAS评分及血清CCL27、TSLP水平均降低,且观察组低于对照组(P<0.05);治疗后1、3个月时,观察组复发率均低于对照组(P<0.05)。结论:清热除湿方辅助咪唑斯汀治疗急性期湿疹患者,可及时缓解瘙痒等症状,降低复发风险,疗效确切,其改善病症的机制可能是抑制CCL27及TSLP水平,调节炎性反应而发挥作用。Objective:To explore the efficacy of Qingre Chushi decoction supplemented with mizolastine in the treatment of eczema and its influence on eczema area,pruritus score and recurrence.Methods:80patients with acute eczema in our hospital were selected as the research subjects from April 2022to January 2023.According to the random number table method,they were divided into control group(n=40)and observation group(n=40).The control group was treated with mizolastine,while the observation group was given Qingre Chushi decoction combined with mizolastine.Both groups were treated for 28days.The clinical efficacy and symptom improvement status after treatment,symptom score[Eczema Area and Severity Index(EASI),Visual Analogue Scale(VAS)]and inflammatory indicators[CC chemokine(CCL)27,thymic stromal lymphopoietin(TSLP)]before and after treatment were compared between groups,and the recurrence of the two groups was analyzed.Results:The total clinical effective rate in observation group was higher compared to control group,and the improvement time of each symptom was shorter than that in control group(P<0.05).The EASI score,VAS score and serum CCL27and TSLP levels in both groups were decreased after 28days of treatment,and the scores and levels in observation group were lower than those in control group(P<0.05).At 1month and 3months after treatment,the recurrence rate was lower in observation group than that in control group(P<0.05).Conclusion:Qingre Chushi decoction supplemented with mizolastine can relieve the pruritus and other symptoms in time,and reduce the risk of recurrence in the treatment of patients with acute eczema,and it has a definite efficacy.The mechanism of improving the symptoms may be to inhibit the levels of CCL27and TSLP and regulate the inflammatory response.

关 键 词：湿疹 急性期 清热除湿方 咪唑斯汀 湿疹面积和严重程度指数 

分 类 号：R275.9[医药卫生—中西医结合]