调任通督电针治疗中晚期宫颈癌肿瘤相关性疲乏的临床观察  

Clinical Observation on Regulating Conception Vessel and Unblocking Governor Vessel Electroacupuncture in the Treatment of Cancer-Related Fatigue in Middle-to-Advanced Stage Cervical Cancer

作　　者：高雅丽[1] 王翠华 赵子申 高雅梅[1] 宋丽娜[1] 王志聪 王洪兵 GAO Yali;WANG Cuihua;ZHAO Zishen;GAO Yamei;SONG Lina;WANG Zhicong;WANG Hongbing(Cangzhou Central Hospital,Cangzhou 061000 Hebei,China;Cangzhou People's Hospital,Cangzhou 061000 Hebei,China)

机构地区：[1]沧州市中心医院,河北沧州061000 [2]沧州市人民医院,河北沧州061000

出　　处：《广州中医药大学学报》2025年第3期683-689,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划资助项目(编号:2022271)。

摘　　要：【目的】观察调任通督电针治疗中晚期宫颈癌肿瘤相关性疲乏(CRF)的临床疗效及对炎症因子的影响。【方法】选取2021年8月至2023年8月沧州市中心医院病房及门诊收治的122例明确诊断为中晚期宫颈癌CRF患者为研究对象。按随机数字表将患者随机分为对照组和观察组,每组各61例。2组患者自化疗当天开始均给予护胃、止呕等常规对症治疗。对照组给予地塞米松片治疗,观察组在对照组治疗的基础上,给予调任通督电针治疗,共治疗21 d。治疗3周后,评价2组临床疗效,观察2组患者治疗前后中医证候积分和Piper疲乏量表(PFS)评分的变化情况,以及Karnofsky功能状态(KPS)评分和癌症患者生命质量测定量表(FACT-G)评分的情况。比较2组患者治疗前后白细胞介素6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)以及T淋巴细胞亚群指标[CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)]的变化情况。【结果】(1)观察组总有效率为95.08%(58/61),对照组为77.05%(47/61)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的中医证候积分均明显改善(P<0.05),且观察组在改善中医证候积分方面明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的PFS评分明显改善(P<0.05),且观察组在改善PFS评分方面明显优于对照组,差异有统计学意义(P<0.05)。(4)治疗后,2组患者的血清IL-6、hs-CRP、TNF-α水平均明显改善(P<0.05),且观察组在改善血清IL-6、hs-CRP、TNF-α水平方面明显优于对照组,差异均有统计学意义(P<0.05)。(5)治疗后,2组患者的CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)均明显改善(P<0.05),且观察组在改善CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)方面明显优于对照组,差异均有统计学意义(P<0.05)。(6)治疗后,2组患者的KPS评分、FACT-G评分均明显改善(P<0.05),且观察组在改善KPS评分、FACT-G评分方面明显优于对照�Objective To observe the clinical efficacy of regulating conception vessel and unblocking governor vessel electroacupuncture in the treatment of cancer-related fatigue(CRF)of middle-to-advanced stage cervical cancer,and to explore its effect on inflammatory factors.Methods A total of 122 patients with a definitive diagnosis of CRF of middle-to-advanced stage cervical cancer admitted to the wards and outpatient clinics of Cangzhou Central Hospital from August 2021 to August 2023 were selected for the study.The patients were randomly divided into the control group and the observation group according to the random number table method,with 61 cases in each group.The patients in both groups were given conventional symptomatic treatments such as gastric protection and anti-vomiting since the day of action of chemotherapy.The control group was treated with Dexamethasone Tablets,and the observation group was treated with regulating conception vessel and unblocking governor vessel electroacupuncture on the basis of the control group,the course of treatment covered 21 days.After three weeks of treatment,the clinical efficacy of the two groups was evaluated.The changes in the traditional Chinese medicine(TCM)syndrome scores,Piper's Fatigue Scale(PFS)scores,Karnofsky Performance Status(KPS)scores,and Functional Assessment of Cancer Therapy-General(FACT-G)scores of the patients in the two groups before and after treatment were observed.The changes in interleukin 6(IL-6),hypersensitive C-reactive protein(hs-CRP),tumor necrosis factorα(TNF-α),and T-lymphocyte subsets indicators[CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)]were compared between the patients in the two groups before and after treatment.Results(1)The total effective rate was 95.08%(58/61)in the observation group and 77.05%(47/61)in the control group.The efficacy of the observation group was superior to that of the control group,the difference being statistically significant(P<0.05).(2)After treatment,the TCM syndrome scores of patients in the two groups were signific

关 键 词：调任通督电针 中晚期宫颈癌 肿瘤相关性疲乏 T淋巴细胞亚群 炎症反应 临床观察 

分 类 号：R246.9[医药卫生—针灸推拿学]