盐酸戊乙奎醚雾化吸入对单肺通气呼吸力学及炎症因子的改善作用研究  

Research on the improvement of respiratory mechanics and inflammation factors in single lung ventilation by nebulized inhalation of pentachloroquine hydrochloride

作　　者：王岩 朱忠权 WANG Yan;ZHU Zhongquan(Department of Anesthesiology,Jinhua People’s Hospital,Zhejiang,Jinhua 321000,China;Department of Anesthesiology,Jinhua Municipal Central Hospital,Zhejiang,Jinhua 321000,China)

机构地区：[1]浙江省金华市人民医院麻醉科,浙江金华321000 [2]浙江省金华市中心医院麻醉科,浙江金华321000

出　　处：《中国医药科学》2025年第4期61-65,共5页China Medicine And Pharmacy

基　　金：金华市科技计划项目(2023-4-106)。

摘　　要：目的探讨盐酸戊乙奎醚雾化吸入对单肺通气呼吸力学及炎症因子的影响。方法选取2023年11月至2024年7月浙江省金华市人民医院收治的60例单肺通气患者为研究对象,按随机数表法将其分为A组(30例)、B组(30例),A组在麻醉诱导前10 min给予患者雾化吸入盐酸戊乙奎醚0.01 mg/kg,B组在麻醉诱导前10 min给予患者静脉注射盐酸戊乙奎醚0.01 mg/kg。比较两组单肺通气前(T1)、单肺通气后10 min(T2)、单肺通气后30 min(T3)、拔管后10 min(T4)呼吸力学相关指标[气道阻力(Raw)、气道峰压(Peak)、呼气末二氧化碳分压(PetCO_(2))、气道平台压(PLat)]、血气指标[氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、氧合指数(OI)]、炎症因子水平[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子(TNF)];比较两组治疗过程中不良反应发生情况。结果两组手术时长、单肺通气时间比较,差异无统计学意义(P>0.05)。T1、T2两组Peak、Raw、PLat、PetCO_(2)、PaO_(2)、PaCO_(2)、OI比较,差异无统计学意义(P>0.05)。T3、T4 A组Peak、Raw、PLat、PetCO_(2)、PaCO_(2)、IL-6、IL-8、TNF水平低于B组,差异有统计学意义(P<0.05);T3、T4 A组PaO_(2)、OI水平高于B组,差异有统计学意义(P<0.05)。A组不良反应总发生率低于B组,差异有统计学意义(P<0.05)。结论盐酸戊乙奎醚雾化吸入能有效改善单肺通气患者肺功能、氧合能力、肺通气功能,降低炎症反应,较为安全。Objective To investigate the impacts of respiratory mechanics and inflammation factors in single lung ventilation by nebulized inhalation of pentachloroquine hydrochloride.Methods A total of 60 patients with single lung ventilation admitted to and treated in Jinhua People’s Hospital from November 2023 to July 2024 were selected as the study subjects.They were divided into Group A(n=30)and Group B(n=30)according to the random number table method.Group A was treated with nebulized inhalation of 0.01 mg/kg pentachloroquine hydrochloride 10 minutes before anesthesia induction,while Group B was treated with intravenous injection of 0.01 mg/kg pentachloroquine hydrochloride 10 minutes before anesthesia induction.Respiratory mechanics related indices(airway resistance[Raw],peak airway pressure[Peak],partial pressure of end-tidal carbon dioxide[PetCO_(2)],plateau pressure[PLat]),blood gas indices(partial pressure of arterial oxygen[PaO_(2)],partial pressure of arterial carbon dioxide[PaCO_(2)],oxygenation index[OI]),and levels of inflammation factors(interleukin-6[IL-6],interleukin-8[IL-8],tumor necrosis factor[TNF])between two groups before single lung ventilation(T1),10 minutes after single lung ventilation(T2),30 minutes after single lung ventilation(T3),and 10 minutes after extubation(T4)were compared.The occurrences of adverse reactions(ADRs)during the treatment process between two groups were compared.Results There were no statistically significant differences in surgical duration and single lung ventilation time between two groups(P>0.05).There were no statistically significant differences in Peak,Raw,PLat,PetCO_(2),PaO_(2),PaCO_(2),and OI between two groups in T1 and T2(P>0.05).The levels of Peak,Raw,PLat,PetCO_(2),PaCO_(2),IL-6,IL-8,and TNF in T3 and T4 in Group A were lower than those in Group B,with statistically significant differences(P<0.05).The levels of PaO_(2) and OI in Group A were higher than those in Group B,with statistically significant differences(P<0.05).The total incidence of ADRs in Group A wa

关 键 词：盐酸戊乙奎醚 雾化吸入 单肺通气 呼吸力学 炎症因子 

分 类 号：R614[医药卫生—麻醉学]