某院不同标本来源产吲哚金黄杆菌感染患者的临床特征分析  

Analysis on the clinical characteristics of patients infected with Chryseobacterium indologenes from different specimen sources in a hospital

作　　者：李红森 王蔚莎 刘丽萍 郭婧 赵越 LI Hongsen;WANG Weisha;LIU Liping;GUO Jing;ZHAO Yue(Department of Clinical Laboratory,Guigang Maternal and Child Health Care Hospital,Guangxi,Guigang 537100,China;Department of Clinical Laboratory,Guangdong Provincial People’s Hospital Affiliated to Southern Medical University,Guangdong Academy of Medical Sciences,Guangdong,Guangzhou 510080,China;Department of Clinical Laboratory,Fo Gang People’s Hospital,Guangdong,Qingyuan 511600,China;Department of Clinical Laboratory,Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region,Guangxi,Nanning 530003,China)

机构地区：[1]广西壮族自治区贵港市妇幼保健院检验科,广西贵港537100 [2]南方医科大学附属广东省人民医院广东省医学科学院检验科,广东广州510080 [3]广东省佛冈县人民医院检验科,广东清远511600 [4]广西壮族自治区妇幼保健院检验科,广西南宁530003

出　　处：《中国医药科学》2025年第4期148-151,180,共5页China Medicine And Pharmacy

摘　　要：目的本研究旨在比较分析广州地区不同标本来源产吲哚金黄杆菌感染的临床特征及耐药情况,为临床诊疗及合理选择抗菌药物提供科学依据。方法回顾性分析2010年1月至2022年12月南方医科大学附属广东省人民医院确诊的76例产吲哚金黄杆菌所致感染患者的临床资料,主要内容包括患者个人信息、基础健康状况、临床感染特征、治疗方案、实验室检测结果以及预后情况等。同时,根据患者预后情况将其分为生存组和死亡组,比较两组患者的临床特征,以及不同标本来源的产吲哚金黄杆菌的耐药情况。结果76株产吲哚金黄杆菌对常用抗菌药物普遍表现出高水平耐药性,其中非呼吸道组环丙沙星、左氧氟沙星、头孢哌酮/舒巴坦的耐药率高于呼吸道组(P<0.05)。此外,在年龄、患有肺部疾病和心脏病、机械通气等方面,生存组与死亡组患者之间的差异有统计学意义(P<0.05)。结论广州地区临床分离的产吲哚金黄杆菌对广谱抗菌药物普遍表现出高度耐药性。因此,医务人员需提高对该菌的认识,加强监测措施,采取科学的防控策略,以减少该菌在医疗机构内的传播。Objective To compare and analyze the clinical characteristics and drug resistance of Chryseobacterium indologenes infections from different specimen sources in Guangzhou,and to provide a scientific basis for clinical diagnosis and treatment and rational selection of antibacterial drugs.Methods The clinical data of 76 patients with infections caused by Chryseobacterium indologenes diagnosed in Guangdong Provincial People’s Hospital Affiliated to Southern Medical University from January 2010 to December 2022 were retrospectively analyzed,which mainly included patients’personal information,basic health status,clinical infection characteristics,treatment regimen,laboratory test results and prognosis.Meanwhile,these patients were divided into the survival group and the death group according to their prognosis.The clinical characteristics of patients and the drug resistance of Chryseobacterium indologenes from different specimen sources were compared between the two groups.Results 74 strains of Chryseobacterium indologenes generally showed a high level of resistance to commonly used antibacterial drugs,with the resistance rates of ciprofloxacin,levofloxacin,and cefoperazone/sulbactam higher in the non-respiratory group than those in the respiratory group(P<0.05).In addition,the differences between patients in the survival and death groups were statistically significant in terms of age,presence of pulmonary and cardiac diseases,and mechanical ventilation(P<0.05).Conclusion Chryseobacterium indologenes clinically isolated in Guangzhou generally show a high level of resistance to broad-spectrum antibacterial drugs.Therefore,medical personnel need to raise awareness of this organism,strengthen monitoring measures,and adopt scientific prevention and controls trategies to reduce the spread of this organism in healthcare facilities.

关 键 词：产吲哚金黄杆菌 标本来源 耐药性 临床特征 

分 类 号：R446.5[医药卫生—诊断学]