基于网络药理学探讨苗药黑骨藤追风活络胶囊治疗类风湿关节炎的作用机制  

Exploring the mechanism of action of Miao medicine Heiguteng Zhuifeng Huoluo capsules in the treatment of rheumatoid arthritis based on network pharmacology

作　　者：何锦悦 HE Jinyue(The Affiliated Yongchuan Hospital of Chongqing Medical University,Chongqing 402160,China)

机构地区：[1]重庆医科大学附属永川医院,402160

出　　处：《临床合理用药》2025年第8期26-29,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：重庆市科委预研项目(YJYY201605)。

摘　　要：目的基于网络药理学探讨苗药黑骨藤追风活络胶囊治疗类风湿关节炎(RA)的多成分、多靶点、多途径的作用机制。方法运用相关药理学数据库、基因库和软件,结合相关文献,对黑骨藤追风活络胶囊的有效组分进行药效物质基础研究;基于GeneCards、OMIM等数据库,筛选RA相关的关键靶点,建立“药物—靶点—通路—疾病”研究模式,对药物发挥作用的成分及靶点构建蛋白质—蛋白质相互作用(PPI)网络图,并对关键靶点进行PPI网络分析。结果获得黑骨藤追风活络胶囊用于治疗RA的有效成分11个,药物靶点603个,疾病靶点4157个,公共靶点352个,有效成分作用通路包括机体细胞增殖、凋亡、血小板激活等过程,还可能参与一氧化氮的合成,与体内多种激素的合成和信号传导有关联性。结论苗药黑骨藤追风活络胶囊对RA有明显的治疗效果,其作用机制与其参与机体细胞增殖、凋亡、信号传导,激素合成、分泌等的调控有关。Objective To explore the multi-component,multi-target and multi-pathway mechanism of action of Miao medicine Heiguteng Zhuifeng Huoluo capsule in the treatment of rheumatoid arthritis(RA)based on network pharmacology.Methods Use relevant pharmacology databases,gene bank and software,combined with relevant literature,its effective pharmacodynamic substances components were studied base,based on the of GeneCards,OMIM et al databases,looking for the key targets associated with RA,and established the research mode of drug-target-pathway-diseases,PPI network map of the components and targets that exert effects on drugs,and to analyze the PPI network of key targets.Results Eleven active ingredients,603 drug targets,4157 disease targets and 352 public targets for the treatment of RA with Heiguteng Zhuifeng Huoluo capsule,and the pathways of action of the active ingredients included cell proliferation,apoptosis,platelet activation,etc,the active ingredients may also be involved in the synthesis of nitric oxide,which is correlated with the synthesis and signaling of many hormones in the body.Conclusion Miao medicine Heiguteng Zhuifeng Huoluo capsules have significant therapeutic effects on RA,their mechanism of action is related to their involvement in the regulation of cell proliferation,apoptosis,and signal transduction,as well as the synthesis and secretion of hormones in the body.

关 键 词：类风湿关节炎 苗药 黑骨藤追风活络胶囊 网络药理学 作用机制 

分 类 号：R28[医药卫生—中药学]