血清成纤维细胞生长因子-1水平与肥胖型支气管哮喘病儿外周血炎症水平、免疫功能及病情严重程度相关性分析  

Correlation analysis between serum FGF-1 level and peripheral blood inflammation level,immune function,and severity of obesity type bronchial asthma in children

作　　者：任海玉 吴雅婷 景燕平 王琴 冯涛 REN Haiyu;WU Yating;JING Yanping;WANG Qin;FENG Tao(Department of Pediatrics,Zhangjiakou Maternal and Child Health Hospital,Zhangjiakou,Hebei 075000,China)

机构地区：[1]张家口市妇幼保健院儿科,河北张家口075000

出　　处：《安徽医药》2025年第4期725-729,共5页Anhui Medical and Pharmaceutical Journal

基　　金：河北省医学科学研究课题项目(20232077)。

摘　　要：目的分析肥胖型支气管哮喘病儿血清成纤维细胞生长因子-1(FGF-1)水平与外周血炎症水平、免疫功能以及病情严重程度的关系。方法选取2017年1月至2020年12月张家口市妇幼保健院收治的120例支气管哮喘病儿作为研究对象,其中肥胖型哮喘组60例,非肥胖哮喘组60例,另选取同期120例健康体检儿童作为对照组。根据肥胖型哮喘病儿病情严重程度分为轻度哮喘29例,中度哮喘24例,重度哮喘7例。检测各组血清FGF-1、补体C3、C4、肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-4、IL-6水平,并分析肺功能系列参数[用力肺活量(FVC)、第1秒用力呼气容积(FEV1%)、最大呼气峰值流速(PEF)、一秒率以及最大呼气中段流量(MMEF)]。结果肥胖型哮喘组FGF-1相对表达水平(6.88±0.37)高于非肥胖哮喘组(5.62±0.21)和健康对照组(2.60±0.87)(P<0.05);肥胖型哮喘组FEV1%、一秒率、PEF、MMEF水平均低于非肥胖哮喘组和健康对照组(P<0.05);肥胖型哮喘重度组FGF-1、补体C3、C4、TNF-α、IL-4、IL-6水平分别为(8.79±1.63)、(2.26±0.47)g/L、(0.75±0.05)g/L、(183.76±46.22)ng/L、(113.44±27.15)ng/L、(18.51±6.03)ng/L均高于轻度组(5.95±1.04)、(1.76±0.28)g/L、(0.51±0.02)g/L、(123.63±16.28)ng/L、(70.53±15.97)ng/L、(8.29±2.54)ng/L及中度组(6.72±0.41)、(1.84±0.25)g/L、(0.55±0.06)g/L、(144.96±22.31)ng/L、(82.50±13.42)ng/L、(11.15±3.12)ng/L(P<0.001);肥胖型哮喘重度组FEV1%、一秒率、MMEF水平均低于轻度及中度组(P<0.05);肥胖型哮喘病儿FGF-1水平与病情严重程度呈正相关(r=0.61,P<0.001),与FEV1%、一秒率呈负相关(r=−0.33,P=0.007;r=−0.42,P<0.001),然而FGF-1与PEF和MMEF之间并无相关性(P>0.05);非肥胖型哮喘病儿FGF-1水平与病情严重程度、肺功能各项指标均无相关性(P>0.05)。结论肥胖型支气管哮喘FGF-1水平较高,与病情严重程度、炎症水平、免疫功能以及肺功能密切相关。Objective To analyze the relationship between serum fibroblast growth factor-1(FGF-1)levels,peripheral blood inflammation levels,immune function,and disease severity in children with obesity-related bronchial asthma.Methods A total of 120 children with bronchial asthma treated in Zhangjiakou Maternal and Child Health Hospital from January 2017 to December 2020 were selected for this study.Of these,60 were in the obesity asthma group and 60 in the non-obesity asthma group.Additionally,120 healthy children undergoing physical examination during the same period were selected as the control group.According to the disease severity of obesity-related asthma,the patients were divided into mild asthma(29 cases),moderate asthma(24 cases),and severe asthma(7 cases).Serum levels of FGF-1,complement C3,C4,tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),and interleukin-6(IL-6)were measured,and pulmonary function parameters[forced vital capacity(FVC),forced expiratory volume in the first second(FEV1%),peak expiratory flow(PEF),FEV1/FVC ratio,and maximal mid-expiratory flow(MMEF)]were analyzed.Results Serum FGF-1 levels in the obesity asthma group(6.88±0.37)were higher than those in the non-obesity asthma group(5.62±0.21)and the healthy control group(2.60±0.87)(P<0.05).Pulmonary function parameters(FEV1%,FEV1/FVC,PEF,MMEF)in the obesity asthma group were lower than those in the non-obesity asthma group and the healthy control group(P<0.05).Serum levels of FGF-1,complement C3,C4,TNF-α,IL-4,and IL-6 in the severe asthma group[(8.79±1.63),(2.26±0.47)g/L,(0.75±0.05)g/L,(183.76±46.22)ng/L,(113.44±27.15)ng/L,(18.51±6.03)ng/L]were higher than those in the mild group[(5.95±1.04),(1.76±0.28)g/L,(0.51±0.02)g/L,(123.63±16.28)ng/L,(70.53±15.97)ng/L,(8.29±2.5)ng/L]and moderate group[(6.72±0.41),(1.84±0.25)g/L,(0.55±0.06)g/L,(144.96±22.31)ng/L,(82.50±13.42)ng/L,(11.15±3.12)ng/L](P<0.001),while pulmonary function parameters(FEV1%,FEV1/FVC,MMEF)were lower in the severe asthma group compared to the mild and moderate g

关 键 词：哮喘 支气管 肥胖 成纤维细胞生长因子-1(FGF-1) 炎症水平 免疫功能 肺功能 儿童 

分 类 号：R725.6[医药卫生—儿科]