Sound innovations for biofabrication and tissue engineering  

作　　者：Mengxi Wu Zhiteng Ma Zhenhua Tian Joseph T.Rich Xin He Jianping Xia Ye He Kaichun Yang Shujie Yang Kam W.Leong Luke P.Lee Tony Jun Huang 

机构地区：[1]School of Mechanical Engineering,Dalian University of Technology,Dalian 116086 Liaoning,China [2]Thomas Lord Department of Mechanical Engineering and Materials Science,Duke University,Durham,NC 27708,USA [3]Department of Mechanical Engineering,Virginia Polytechnic Institute and State University,Blacksburg,VA 24060,USA [4]Department of Biomedical Engineering,Duke University,Durham,NC 27708,USA [5]Renal Division and Division of Engineering in Medicine,Department of Medicine,Brigham and Women’s Hospital,Harvard Medical School,Boston,MA 02115,USA [6]Department of Biomedical Engineering,Columbia University,New York,NY 10027,USA

出　　处：《Microsystems & Nanoengineering》2024年第6期1-19,共19页微系统与纳米工程(英文)

基　　金：support from the National Institutes of Health(R01GM132603,R01GM135486,R01GM144417,UH3TR002142,and UG3TR002978);the National Science Foundation(ECCS-1807601,CMMI-2243771,CMMI-2340016,and CMMI-2104526);supported by the National Science Foundation Graduate Research Fellowship(Grant No.1644868).

摘　　要：Advanced biofabrication techniques can create tissue-like constructs that can be applied for reconstructive surgery or as in vitro three-dimensional(3D)models for disease modeling and drug screening.While various biofabrication techniques have recently been widely reviewed in the literature,acoustics-based technologies still need to be explored.The rapidly increasing number of publications in the past two decades exploring the application of acoustic technologies highlights the tremendous potential of these technologies.In this review,we contend that acoustics-based methods can address many limitations inherent in other biofabrication techniques due to their unique advantages:noncontact manipulation,biocompatibility,deep tissue penetrability,versatility,precision in-scaffold control,high-throughput capabilities,and the ability to assemble multilayered structures.We discuss the mechanisms by which acoustics directly dictate cell assembly across various biostructures and examine how the advent of novel acoustic technologies,along with their integration with traditional methods,offers innovative solutions for enhancing the functionality of organoids.Acoustic technologies are poised to address fundamental challenges in biofabrication and tissue engineering and show promise for advancing the field in the coming years.

关 键 词：ACOUSTICS LIMITATIONS INNOVATIVE 

分 类 号：R318.08[医药卫生—生物医学工程]