Defect-insensitive cylindrical surface lattice resonance array and its batch replication for enhanced immunoassay  

作　　者：Bin Zhou Chao Hu Haoyang Li Xiangyi Ye Baohua Wen Zhangkai Zhou Jingxuan Cai Jianhua Zhou 

机构地区：[1]Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province,School of Biomedical Engineering,Shenzhen Campus of Sun Yat-sen University,518107 Shenzhen,China [2]School of Physics,State Key Laboratory of Optoelectronic Materials and Technologies,Sun Yat-sen University,510275 Guangzhou,China

出　　处：《Microsystems & Nanoengineering》2024年第6期151-160,共10页微系统与纳米工程(英文)

基　　金：support from the National Key Research and Development Plan(2021YFA1400804);the National Natural Science Foundation of China(Nos.22174167,21775168,62205382);Guangdong Basic and Applied Basic Research Foundation(Nos.2021A1515110388,2024A1515011707);the Foundation of Sun Yat-sen University(No.76190-18841213);Key Basic Research Project of Shenzhen Natural Science Foundation(No.JCYJ20220818102014028);the Foundation of Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument(No.2020B1212060077).

摘　　要：Surface lattice resonances(SLR)have been demonstrated to enhance the sensitivity and reduce the full width at half maximum(FWHM)of the plasmonic resonances.However,their widespread application in immunoassays has been hindered by limitations of high structural defect sensitivity and fabrication costs.Here,we design a novel three-layer cylindrical SLR array that exhibits high tolerance against structural defects,which would facilitate straightforward fabrication.By integrating metal evaporation and nanoimprint lithography,we demonstrate the replication of the SLR array with exceptional quality.Theoretical simulations indicate that the resonance dips of these arrays exhibit are not sensitive to various structural defects.The experimental results reveal that the FWHM of these arrays can be as low as 5.1 nm while maintaining robust resonance characteristics.Furthermore,we demonstrated the high spectral sensitivity of the SLR array,which enabled the detection of immunoglobulin G(IgG)at concentrations as low as 609 pg/mL.These findings emphasize the potential of the defect-insensitive SLR array as a highly scalable immunoassay platform with exceptional performance.

关 键 词：CYLINDRICAL insensitive RESONANCE 

分 类 号：R318.08[医药卫生—生物医学工程]