Chronic wound management:a liquid diode-based smart bandage with ultrasensitive pH sensing ability  

作　　者：Xueqi Wang Jing Cheng Han Wang 

机构地区：[1]School of Biomedical Engineering,Tsinghua University,Beijing 100084,China [2]National Engineering Research Center for Beijing Biochip Technology,Beijing 102206,China

出　　处：《Microsystems & Nanoengineering》2024年第6期403-417,共15页微系统与纳米工程(英文)

基　　金：supported by a National Natural Science Foundation of China grant(82272121)to H.W.

摘　　要：Chronic wounds,which require prolonged healing periods,pose significant impacts on individuals with diabetes,vascular diseases,and high blood pressure.Simultaneous drainage and monitoring of wound exudate are vital for advanced wound management.However,recently reported smart dressings either lack integration of wound cleaning and monitoring functions or fail to achieve dynamic in situ monitoring of wound status,which hinders their ability to meet the demands of wound care.In this study,a smart bandage is introduced,which integrates a biocompatible liquid diode membrane with an ultrasensitive 3D polyaniline mesh(M-PANI)-based pH biosensor.The smart bandage allows for unidirectional drainage of wound exudate while dynamically sensing the wound pH environment.Specifically,the proposed smart bandage effectively cleans excessive wound exudate while providing real-time information on the wound status during the drainage process.The M-PANI-based pH biosensor demonstrates a high sensitivity of 61.5 mV/pH and a wide pH detection range from 4.0 to 10.0,encompassing the pH range of normal and infected wounds.Moreover,the sensing module exhibits excellent stability after 48 hours of dynamic testing and 28 days of storage,with only a 4.8%decline in the detected signal,and high repeatability with a device-to-device relative standard deviation(RSD)of 3.1%.To evaluate the practicality of this smart bandage,simulated skin and rats have been employed,and the results indicate the immense potential of this smart bandage for clinical applications.In conclusion,the present smart bandage demonstrates considerable promise for wound exudate cleaning and monitoring in advanced wound care and offers a promising method for home-based wound management.

关 键 词：WOUND SMART CONCLUSION 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]