不同形貌Lu_(2)O_(3):Yb,Tm/MC540上转换纳米材料用于肿瘤光动力治疗研究  

Lu_(2)O_(3):Yb,Tm/MC540 Up-Conversion Nanomaterials with Different Morphologies for Photodynamic Therapy of Tumor

作　　者：王国薇 韩丽君 潘思文 张洪光 张英博 WANG Guowei;HAN Lijun;PAN Siwen;ZHANG Hongguang;ZHANG Yingbo(College of Pathology,Qiqihar Medical University,Qiqihar 161006,China;College of Pharmacy,Qiqihar Medical University,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔医学院病理学院,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院药学院,黑龙江齐齐哈尔161006

出　　处：《化学与生物工程》2025年第3期56-60,共5页Chemistry & Bioengineering

基　　金：2020年黑龙江省省属本科高校基本科研业务费资助项目(2020-KYYWF-0006)。

摘　　要：采用水热法制备了3种不同形貌的Lu_(2)O_(3):Yb,Tm上转换纳米材料,随后原位负载光敏剂部花青(MC540),制备了Lu_(2)O_(3):Yb,Tm/MC540上转换纳米材料,通过XRD、FTIR和SEM等对Lu_(2)O_(3):Yb,Tm上转换纳米材料的晶相、表面基团和形貌进行了表征,研究了Lu_(2)O_(3):Yb,Tm/MC540上转换纳米材料的光动力抗肿瘤性能。结果表明,Lu_(2)O_(3):Yb,Tm上转换纳米材料的荧光光谱与MC540的紫外可见吸收光谱匹配良好;在980 nm激光照射下,Lu_(2)O_(3):Yb,Tm上转换纳米材料发出的蓝色荧光可以有效激发MC540产生活性氧;3种不同形貌的Lu_(2)O_(3):Yb,Tm/MC540上转换纳米材料均可对人乳腺癌细胞MCF-7造成杀伤。We firstly prepared three kinds of Lu_(2)O_(3):Yb,Tm up-conversion nanomaterials with different morphologies by a hydrothermal method,then prepared Lu_(2)O_(3):Yb,Tm/MC540 up-conversion nanomaterials by loading partial cyanine(MC540)photosensitizer in situ.Moreover,we characterized the crystal phase,surface groups,and morphology of Lu_(2)O_(3):Yb,Tm up-conversion nanomaterials by XRD,FTIR,and SEM,and studied the photodynamic anti-tumor performance of Lu_(2)O_(3):Yb,Tm/MC540 up-conversion nanomaterials.The results show that the fluorescence spectrum of Lu_(2)O_(3):Yb,Tm up-conversion nanomaterials matches well with the UVvisible absorption spectrum of MC540.Under 980 nm laser irradiation,the blue fluorescence emitted by Lu_(2)O_(3):Yb,Tm up-conversion nanomaterials can effectively stimulate MC540 to produce reactive oxygen species.In addition,three kinds of Lu_(2)O_(3):Yb,Tm/MC540 up-conversion nanomaterials with different morphologies can effectively kill human breast cancer cells MCF-7.

关 键 词：Lu_(2)O_(3):Yb Tm/MC540 形貌 光动力 上转换 抗肿瘤 

分 类 号：O614.33[理学—无机化学] O482.31[理学—化学]