Exosomal mediators in sepsis and inflammatory organ injury:unraveling the role of exosomes in intercellular crosstalk and organ dysfunction  

作　　者：Ting Gong You-Tan Liu Jie Fan 

机构地区：[1]Department of Surgery,University of Pittsburgh School of Medicine,Pittsburgh,PA 15213,USA [2]Department of Anesthesiology,Shenzhen Hospital,Southern Medical University,Shenzhen 518110,Guangzhou,China [3]Research and Development,Veterans Affairs Pittsburgh Healthcare System,Pittsburgh,PA 15240,USA [4]Department of Immunology,University of Pittsburgh School of Medicine,Pittsburgh,PA 15213,USA [5]McGowan Institute for Regenerative Medicine,University of Pittsburgh,Pittsburgh,PA 15219,USA

出　　处：《Military Medical Research》2025年第2期264-284,共21页军事医学研究(英文版)

基　　金：USA National Institutes of Health Grant(R01-HL-139547,to JF);USA VA Grants(1I01BX004838 and IK6BX004211,to JF);National Natural Science Foundation of China(82002087,to TG);Shenzhen Science and Technology Program(JCYJ20210324134602008,to TG)。

摘　　要：Sepsis,a severe systemic inflammatory response to infection,remains a leading cause of morbidity and mortality worldwide.Exosomes,as mediators of intercellular communication,play a pivotal role in the pathogenesis of sepsis through modulating immune responses,metabolic reprogramming,coagulopathy,and organ dysfunction.This review highlights the emerging significance of exosomes in these processes.Initially,it provides an in-depth insight into exosome biogenesis and characterization,laying the groundwork for understanding their diverse and intricate functions.Subsequently,it explores the regulatory roles of exosomes in various immune cells such as neutrophils,macrophages,dendritic cells,T cells,and B cells.This analysis elucidates how exosomes are pivotal in modulating immune responses,thus contributing to the complexity of sepsis pathophysiology.Additionally,this review delves into the role of exosomes in the regulation of metabolism and subsequent organ dysfunction in sepsis.It also establishes a connection between exosomes and the coagulation cascade,which affects endothelial integrity and promotes thrombogenesis in sepsis.Moreover,the review discusses the dual role of exosomes in the progression and resolution of sepsis,exploring their complex involvement in inflammation and healing processes.Furthermore,it underscores their potential as biomarkers and therapeutic targets.Understanding these mechanisms presents new opportunities for novel interventions to mitigate the severe outcomes of sepsis,emphasizing the therapeutic promise of exosome research in critical care settings.

关 键 词：SEPSIS EXOSOMES Intercellular crosstalk Inflammation Biomarkers 

分 类 号：R459.7[医药卫生—急诊医学]