一款潮热喷雾降温和凉感的临床研究  

Clinical study on a cooling and refreshing effects of a hot flash spray

作　　者：赵雪华 刘建伟 郭萌 彭先武 吴梦洁 林文强 ZHAO Xuehua;LIU Jianwei;GUO Meng;PENG Xianwu;WU Mengjie;LIN Wenqiang(Amway(Shanghai)Technology Development Co.,Ltd.,Shanghai 201203,China;Amway(China)R&D Centre Co.,Ltd,Guangzhou,Guangdong 510730,China;Shanghai Shengping Co.,Ltd.,Shanghai 200433,China)

机构地区：[1]安利(上海)科技发展有限公司,上海201203 [2]安利(中国)研发中心有限公司,广东广州510730 [3]上海盛评检测技术有限公司,上海200433

出　　处：《日用化学品科学》2025年第3期33-38,共6页Detergent & Cosmetics

摘　　要：采用仪器评估和志愿者主观评价法,开发了一种同步测量皮肤实际温度和评估凉感的人体功效测试方法,对感觉上的凉感进行了定量分析,并通过此方法评价了一款自研潮热喷雾对更年期人群降温和带来凉感的效果。招募31名更年期健康志愿者作为研究对象,通过红外热成像和脑电波(EEG)测量技术,分别在基线(BL)、模拟潮热状态后即刻(HF)、使用测试产品后1 min(T1)、3 min(T3)和5 min(T5)的时间点,同时采集志愿者脸颊的皮肤温度和脑电波数据。结果表明,与HF相比,使用潮热喷雾后,脸颊皮肤温度降低,分别在使用后的T1、T3、T5显著降低了8.75%、8.75%和6.41%(P<0.05);脑电波α-1功率值增加,分别在使用后的T1、T3、T5显著增加了59.70%、58.44%和51.39%(P<0.05)。该潮热喷雾在实际降低皮肤温度的同时,也为志愿者带来感觉上的凉感,能够缓解更年期女性潮热。An instrumental assessment and volunteer subjective evaluation method was developed to synchronously measure the actual skin temperature and evaluate the cool sensation,conducting a quantitative analysis of the perceived coolness.This method was used to evaluate the effect of a self-developed hot flash spray on reducing the skin temperature and inducing the cooling sensation of menopausal individuals.31 healthy menopausal volunteers were recruited as the research subjects.Using infrared thermal imaging and electroencephalogram(EEG)measurements,the skin temperature and EEG data of the subjects’cheeks were simultaneously collected at baseline(BL),immediately after simulated hot flashes(HF),1 min(T1),3 mins(T3),and 5 min(T5)after the application of the test sample.The results showed that,compared with HF,the skin temperature of cheek was significantly reduced by 8.75%,8.75%,and 6.41% at T1,T3,and T5(P<0.05),respectively.And alpha-1 value of EEG was increased significantly by 59.70%,58.44%,and 51.39% at T1,T3,and T5(P<0.05),respectively.The hot flash spray effectively reduces skin temperature while also provides subjects with a feeling of coolness,which can relieve hot flashes in menopausal women.

关 键 词：潮热 更年期 降温 凉感 瞬时受体电位褪黑素抑制素8(TRPM8) 脑电波(EEG) 

分 类 号：TQ658[化学工程—精细化工]