瓜尔胶来源的半乳甘露聚糖在化妆品领域的应用研究  

Application research of galactomannan derived from guar gum in the field of cosmetics

作　　者：吴晗 王颖 苏宁[1] 张颖 王懿敏 王莉娜 张思淼 闫妍[1] 刘燕静 龚征晨 WU Han;WANG Ying;SU Ning;ZHANG Ying;WANG Yimin;WANG Lina;ZHANG Simiao;YAN Yan;LIU Yanjing;GONG Zhengchen(Cosmetics Technology Center,Chinese Academy of Inspection and Quarantine,Beijing 100176,China;Beijing Guaran Science and Technology Co.,Ltd.,Beijing 101300,China)

机构地区：[1]中国检验检疫科学研究院化妆品技术中心,北京100176 [2]北京瓜尔润科技股份有限公司,北京101300

出　　处：《日用化学品科学》2025年第3期46-54,共9页Detergent & Cosmetics

基　　金：中国检科院基本科研业务费项目(2022JK26)。

摘　　要：研究了瓜尔豆来源的半乳甘露聚糖在化妆品中使用的安全性及保湿功效。通过细胞毒性、急性皮肤刺激、急性眼刺激、光毒性,验证了半乳甘露聚糖的安全性;利用物理法、生物化学法、细胞生物法3种不同的实验方法,验证了其在皮肤保湿剂方面的功效。研究表明,半乳甘露聚糖能够有效促进HACaT细胞天然保湿因子AQP3表达,改善皮肤保湿能力;在1.250%,2.500%,5.000%能够抵御干燥对HACaT细胞的损伤,提升细胞存活能力与半乳甘露聚糖浓度成正比;在抑制透明质酸酶方面,同在低浓度下半乳甘露聚糖与甘油效果接近,均能明显提高透明质酸酶抑制率,且优于β-葡聚糖保湿剂。The safety and moisturizing efficacy of galactomannan derived from guar gum in cosmetics were investigated.The safety of galactomannan was verified by cytotoxicity,acute skin irritation,acute eye irritation,and phototoxicity experiments,while its efficacy as a skin moisturizer was verified by three different experimental methods:physical,biochemical,and cell biology method.Results showed that galactomannan can effectively promote the expression of AQP3,a natural moisturizing factor in HACaT cells,and improve the skin’s moisturizing ability.At 1.250%,2.500%,and 5.000%,it can resist the damage of drying to HACaT cells and improve cell survival ability,while the improvement in cell survival ability is proportional to the concentration of galactomannan.In terms of inhibiting hyaluronidase,at the same low concentration,galactomannan showed superior performance to β-glucan whereas exhibiting comparable performances as glycerol,both galactomannan and glycol can significantly increase hyaluronidase inhibition.Therefore,galactomannan has excellent moisturizing effects in multiple dimensions,illustrating its prospects for wide usage in the field of moisturizing cosmetics.

关 键 词：瓜尔胶 半乳甘露聚糖 安全性 保湿 

分 类 号：TQ658[化学工程—精细化工]