高尿酸血症患者胫前动脉粥样硬化的影响因素分析  

Influencing factors for anterior tibial artery atherosclerosis among patients with hyperuricemia

作　　者：孙露[1] 郑东[1] 张洪超 SUN Lu;ZHENG Dong;ZHANG Hongchao(Dazhou Integrated TCM&Western Medicine Hospital,Dazhou,Sichuan 635000,China)

机构地区：[1]达州市中西医结合医院,四川达州635000

出　　处：《预防医学》2025年第3期288-291,295,共5页China Preventive Medicine Journal

摘　　要：目的了解高尿酸血症患者胫前动脉粥样硬化的影响因素,为预防高尿酸血症患者胫前动脉粥样硬化提供参考。方法选择2020—2023年在达州市中西医结合医院就诊的≥18岁高尿酸血症患者为研究对象,通过电子病历收集人口学信息和血生化指标等资料,采用彩色多普勒超声评估胫前动脉粥样硬化情况;采用多因素logistic回归模型分析高尿酸血症患者胫前动脉粥样硬化的影响因素。结果调查高尿酸血症患者1105例,其中男性862例,占78.01%;女性243例,占21.99%。年龄≥60岁918例,占83.08%。病程≥10年457例,占41.36%。血尿酸水平M(QR)为480.79(98.28)μmol/L。高尿酸血症患者胫前动脉粥样硬化314例,占28.42%。多因素logistic回归分析结果显示,体质指数(≥24.0 kg/m^(2),OR=1.597,95%CI:1.185~2.151)、长期吸烟史(有,OR=1.709,95%CI:1.153~2.534)、糖尿病(有,OR=1.517,95%CI:1.162~1.981)、血尿酸(≥480.79μmol/L,OR=1.667,95%CI:1.131~2.457)、血肌酐(≥97μmol/L,OR=1.685,95%CI:1.155~2.460)、空腹血糖(≥6.1 mmol/L,OR=1.528,95%CI:1.106~2.112)、纤维蛋白原(>4 g/L,OR=1.589,95%CI:1.091~2.315)、三酰甘油(≥1.7 mmol/L,OR=1.879,95%CI:1.226~2.881)是高尿酸血症患者胫前动脉粥样硬化的影响因素。结论高尿酸血症患者胫前动脉粥样硬化主要与长期吸烟、糖尿病和血尿酸、血肌酐、空腹血糖、纤维蛋白原、三酰甘油水平高有关。Objective To analyze the influencing factors for anterior tibial artery atherosclerosis among patients with hyperuricemia,so as to provide insights into the prevention of anterior tibial artery atherosclerosis.Methods Patients aged 18 years and older with hyperuricemia in Dazhou Integrated TCM&Western Medicine Hospital were enrolled as research subjects from 2020 to 2023.Demographic information and blood biochemistry indicators were collected through electronic medical records.Anterior tibial artery atherosclerosis was evaluated by color Doppler ultrasound.Factors affecting anterior tibial artery atherosclerosis among patients with hyperuricemia were analyzed by a multivariable logistic regression model.Results A total of 1105 patients with hyperuricemia were surveyed,including 862 males(78.01%)and 243 females(21.99%).There were 918 cases(83.08%)at the ages of 60 years and older,and 457 cases(41.36%)with a course of disease at 10 years and longer.The median level of blood uric acid was 480.79(interquartile range,98.28)μmol/L.There were 314 cases(28.42%)with anterior tibial artery atherosclerosis.Multivariable logistic regression analysis showed that body mass index(≥24.0 kg/m^(2),OR=1.597,95%CI:1.185-2.151),long-term smoking history(yes,OR=1.709,95%CI:1.153-2.534),diabetes mellitus(yes,OR=1.517,95%CI:1.162-1.981),serum uric acid(≥480.79μmol/L,OR=1.667,95%CI:1.131-2.457),serum creatinine(≥97μmol/L,OR=1.685,95%CI:1.155-2.460),fasting blood glucose(≥6.1 mmol/L,OR=1.528,95%CI:1.106-2.112),fibrinogen(>4 g/L,OR=1.589,95%CI:1.091-2.315)and triglycerides(≥1.7 mmol/L,OR=1.879,95%CI:1.226-2.881)were influencing factors for anterior tibial artery atherosclerosis among patients with hyperuricemia.Conclusion Anterior tibial artery atherosclerosis among patients with hyperuricemia is associated with long-term smoking,diabetes mellitus,serum uric acid,serum creatinine,fasting blood glucose,fibrinogen and triglycerides high level.

关 键 词：高尿酸血症 胫前动脉粥样硬化 影响因素 

分 类 号：R587.2[医药卫生—内分泌]