香榧中1个新的木脂素  

One new lignan from Torreya grandis var.merrillii

作　　者：拉目加 蒙俞帆 袁菁菁 郭大乐 何达海[1] 肖世基 LA Mujia;MENG Yufan;YUAN Jingjing;GUO Dale;HE Dahai;XIAO Shiji(College of Pharmacy and Food,Southwest Minzu University,Chengdu 610041,China;School of Pharmacy,Zunyi Medical University,Zunyi 563006,China;School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]西南民族大学药学与食品学院,四川成都610041 [2]遵义医科大学药学院,贵州遵义563006 [3]成都中医药大学药学院,四川成都611137

出　　处：《中草药》2025年第3期765-770,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(31560102);中央高校基本科研业务费专项基金(ZYN2024008);科技基础资源调查专项资助(2022FY102000)——民族医药疫病文献辑录及其防治疫病的经验研究(2022FY102004)。

摘　　要：目的研究香榧Torreya grandis的化学成分。方法采用各种类型柱色谱及半制备液相色谱进行分离纯化,经波谱数据鉴定化合物结构,MTT法检测化合物的肿瘤细胞毒活性。结果从香榧树皮中分离鉴定了4个木脂素类化合物,分别为(8R,7′S,8′R)-4,4′-二羟基-3,3′,5′,7′-四甲氧基木脂烷-9,9′-内酯(1)、桧脂素(2)、扁柏脂素(3)和traxillagenin(4)。结论化合物1为新的木脂素类化合物,命名为香榧木脂素A;其余化合物均为首次从香榧中分离得到。化合物2~4在20μmol/L浓度下对HCT-116和AsPC-1癌细胞有一定的抑制作用。Objective To elucidate the chemical constituents of Torreya grandis var.merrillii.Methods The compounds were isolated and purified using various methods,including column chromatography and semi-preparative liquid chromatography.The structures of the isolated compounds were identified through spectral data analysis.The cytotoxic activities of these compounds were assessed using the MTT assay.Results A total of four lignan compounds were isolated,and their structures were identified as follows:(8R,7′S,8′R)-4,4′-dihydroxy-3,3′,5′,7′-tetramethoxy-lignane-9,9′-lactone(1),savinin(2),hinokinin(3),and traxillagenin(4).Conclusion Compound 1 is a new compound named torregrandlignan A,while the remaining compounds were isolated for the first time from T.grandis var.merrillii.Compounds 2—4 exhibited moderated cytotoxic activity against HCT-116 and AsPC-1 cells.

关 键 词：红豆杉科 榧树属 香榧 木脂素 香榧木脂素A 桧脂素 扁柏脂素 

分 类 号：R284.1[医药卫生—中药学]