绞股蓝资源分布、化学成分、检测方法及药理作用研究进展  

Research progress on resource distribution,chemical composition,detection methods and pharmacological effects of Gynostemma pentaphyllum

作　　者：葛锦蓉 张子仪 张兴明 覃桂 李荣胜 汪波 GE Jinrong;ZHANG Ziyi;ZHANG Xingming;QIN Gui;LI Rongsheng;WANG Bo(Hubei Institute for Drug Control,Wuhan 430075,China;Key Laboratory of Quality Control of Chinese Medicine,National Medical Products Administration,Wuhan 430075,China;College of Horticulture,Shanxi Agricultural University,Jinzhong 030801,China;Shanghai Huanghai Pharmaceutical Co.,Ltd.,Shanghai 200942,China)

机构地区：[1]湖北省药品监督检验研究院,湖北武汉430075 [2]国家药品监督管理局中药质量控制重点实验室,湖北武汉430075 [3]山西农业大学园艺学院,山西晋中030801 [4]上海黄海制药有限责任公司,上海200942

出　　处：《中草药》2025年第3期1050-1063,共14页Chinese Traditional and Herbal Drugs

基　　金：2024年度湖北省技术创新计划重大项目(2024BCA002)。

摘　　要：绞股蓝Gynostemma pentaphyllum是具有清热解毒、止咳祛痰、健脾益气之效的药食同源中药。研究表明其含有丰富的化学成分及药理活性,其中代表性皂苷类成分具有抗动脉粥样硬化、抗骨质松疏松、调血脂、调血压、调节肠道菌群及保肝等作用;多糖类成分具有调节免疫、生殖系统及保肝等作用。目前市场开发了绞股蓝药品、保健品及化妆品等,市场应用前景广阔,具备一定的开发利用价值。通过综述绞股蓝资源分布、化学成分、检测方法及药理作用等方面研究现状及进展,为绞股蓝的药食两用资源的合理开发和综合利用提供思路。Jiaogulan(Gynostemma pentaphyllum)is a traditional Chinese medicine of homology of medicine and food with the effect of clearing heat and detoxifying,relieving cough and eliminating phlegm,strengthening spleen and replenishing qi.Studies have shown that it is rich in chemical constituents and pharmacological activities.The representative saponins have the effects of anti-atherosclerosis,anti-osteoporosis,lowering blood lipid,adjusting blood pressure,regulating intestinal flora and protecting liver.Polysaccharides have the functions of regulating immunity,reproductive system and liver protection.At present,the market has developed medicines,health products and cosmetics of G.pentaphyllum,etc.,it has high market prospects,certain development and utilization value.This paper reviews the researches and progress about resources distribution,chemical composition,detection methods and pharmacological effects of G.pentaphyllum,in order to provide ideas for the rational development and comprehensive utilization of dual-use resources of G.pentaphyllum.

关 键 词：绞股蓝 资源分布 检测方法 皂苷类 黄酮类 多糖类 有机酸类 保肝作用 

分 类 号：R28[医药卫生—中药学]