山茱萸治疗糖尿病肾病作用机制研究进展  

Research progress on mechanism of Corni Fructus in treatment of diabetic nephropathy

作　　者：赵丹麦 钟睿 王晓天 闫忠红 ZHAO Danmai;ZHONG Rui;WANG Xiaotian;YAN Zhonghong(School of Basic Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学基础医学院,黑龙江哈尔滨150040

出　　处：《中草药》2025年第3期1078-1087,共10页Chinese Traditional and Herbal Drugs

基　　金：黑龙江省医药卫生科研课题(20230202080141)。

摘　　要：糖尿病肾病(diabetic nephropathy,DN)是糖尿病最常见的并发症之一,发病机制复杂,随着肾脏中肾小球、肾小管和肾间质等不断被破坏,最终可发展为慢性肾脏病(chronic kidney disease,CKD)和终末期肾病(end-stage renal disease,ESRD),需要进行长期的持续治疗。山茱萸Corni Fructus首载于《神农本草经》,具有补益肝肾、收涩固脱的功效,是保护肾脏的代表性药物。研究表明,山茱萸能够通过抑制炎症、减少氧化应激、调节自噬及肠道菌群等方式降低血糖、减少足细胞凋亡、缓解肾脏病理损伤、改善肾脏纤维化状况。对DN的病因病机进行了阐释,总结了山茱萸中的部分有效成分如山茱萸新苷、莫诺苷、马钱苷,山茱萸提取物,炮制山茱萸以及山茱萸药对和复方在治疗DN方面的作用机制及研究进展,为临床应用山茱萸治疗DN提供依据,为山茱萸的进一步研究与开发应用提供参考。Diabetic nephropathy(DN)is one of the most common complications of diabetes mellitus with complex pathogenesis.With the continuous destruction of glomeruli,tubules and interstitium in the kidney,it can eventually develop into chronic kidney disease(CKD)and end-stage renal disease(ESRD),which requires long-term continuous treatment.Shanzhuyu(Corni Fructus),first published in the Shen Nong’s Herbal Classic,has the efficacy of tonifying the liver and kidneys,relieving collapse with astringent therapy,and is a representative medicine for protecting the kidneys.Studies have shown that Corni Fructus is able to lower blood glucose,reduce podocyte apoptosis,alleviate renal pathological damage and improve renal fibrosis by inhibiting inflammation,reducing oxidative stress,and regulating autophagy and gut flora.This paper elucidates the etiology and pathogenesis of DN,summarizes the mechanism of action and research progress of some of the active components in Corni Fructus,such as cornuside,morroniside and loganin,Corni Fructus extracts,processing Corni Fructus,as well as Corni Fructus medicinal pairs and combinations in the treatment of DN.It provides a basis for the clinical application of Corni Fructus in the treatment of diabetic nephropathy and a reference for further research and development of Corni Fructus applications.

关 键 词：糖尿病肾病 山茱萸 山茱萸新苷 马钱苷 莫诺苷 

分 类 号：R285[医药卫生—中药学]