有毒中药配伍减毒的研究现状及发展思考  

Current status and development considerations of detoxification research on toxic traditional Chinese medicine compatibility

作　　者：邵远洋 张晨宁 王娟[1] 吴梦娟 段佳佳 孙璐 王玉华 李丁 董一鑫 王蕾 孔娇 代一航 刘传鑫 SHAO Yuanyang;ZHANG Chenning;WANG Juan;WU Mengjuan;DUAN Jiajia;SUN Lu;WANG Yuhua;LI Ding;DONG Yixin;WANG Lei;KONG Jiao;DAI Yihang;LIU Chuanxin(Department of Chinese Medicine,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Pharmacy,Xiangyang No.1 Peoples Hospital,Hubei University of Medicine,Xiangyang 441000,China;Department of Clinical Laboratory,The First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China;College of Chinese Materia Medica and Food Engineering,Shanxi University of Chinese Medicine,Jinzhong 030619,China;Department of Emergency,The First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China;Department of Pharmacy,The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital,Zhengzhou 450008,China;Luoyang Orthopedic-Traumatological Hospital of Henan Province(Henan Provincial Orthopedic Hospital),Zhengzhou 450016,China;Laboratory of Drug Metabolism and Pharmaceutical Analysis,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;College of Medicine,Xinyang Normal University,Xinyang 464000,China;Luoyang Key Laboratory of Clinical Multiomics and Translational Medicine,Key Laboratory of Hereditary Rare Diseases of Health Commission of Henan Province,Henan Key Laboratory of Rare Diseases,Endocrinology and Metabolism Center,The First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]郑州大学第一附属医院中药科,河南郑州450000 [2]湖北医药学院附属襄阳市第一人民医院药学部,湖北襄阳441000 [3]河南科技大学临床医学院,河南科技大学第一附属医院检验科,河南洛阳471003 [4]山西中医药大学中药与食品工程学院,山西晋中030619 [5]河南科技大学临床医学院,河南科技大学第一附属医院急诊科,河南洛阳471003 [6]郑州大学附属肿瘤医院(河南省肿瘤医院)药学部,河南郑州450008 [7]河南省洛阳正骨医院(河南省骨科医院),河南郑州450016 [8]浙江大学药学院药物代谢和药物分析研究所,浙江杭州310058 [9]信阳师范大学医学院,河南信阳464000 [10]河南科技大学临床医学院,河南科技大学第一附属医院内分泌代谢中心,河南省罕见病重点实验室,河南省卫生健康委遗传罕见病重点实验室,洛阳市临床多组学与转化医学重点实验室,河南洛阳471003

出　　处：《中草药》2025年第4期1394-1403,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82204938);国家自然科学基金资助项目(82404774);国家自然科学基金资助项目(82404736);河南省医学科技攻关计划项目(LHGJ20240427);湖北省教育厅重点项目(D20232101);襄阳市第一人民医院科研创新项目(XYY2023ZY01);湖北医药学院附属襄阳市第一人民医院博士科研启动金(XYY2023D05)。

摘　　要：合理使用有毒中药是保障中药安全的关键,配伍是中药减毒有效措施之一。通过对当前中药配伍减毒的评价模型、减毒方法、减毒技术及减毒机制进行梳理,同时针对目前中药配伍减毒存在的西医模式化研究思路的既定困局及如何在中医药理论指导下开展有毒中药配伍减毒的现代化研究提出了客观建议,为有毒中药配伍减毒研究体系的进一步完善规避用药风险和指导安全用药提供保障。The prudent use of potentially toxic traditional Chinese medicine(TCM)is essential for ensuring its safety,with compatibility serving as a critical strategy for mitigating toxicity.This article presented a comprehensive review of the evaluation models,methodologies,techniques,and mechanisms associated with TCM compatibility for toxicity reduction.Additionally,it provided objective recommendations for conducting modern research on TCM compatibility within the framework of TCM theory.The goal is to enhance the research system focused on TCM compatibility for toxicity reduction,minimize medication-related risks and promote safe medication practices.

关 键 词：中药 减毒 配伍 毒理证据链 体质毒理学 量-权-证网络毒理学 

分 类 号：R28[医药卫生—中药学]