葛根在治疗炎症性肠病中的作用机制和应用研究进展  

Research progress on mechanism and application of Puerariae Lobatae Radix in treatment of inflammatory bowel disease

作　　者：李欢[1,2] 张相安 LI Huan;ZHANG Xiangan(Department of Anorectology,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China;Anorectal Disease Diagnosis and Treatment Center,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院肛肠科,河南郑州450000 [2]河南中医药大学第一临床医学院,河南郑州450046 [3]河南中医药大学第一附属医院肛肠病诊疗中心,河南郑州450000

出　　处：《中草药》2025年第4期1428-1439,共12页Chinese Traditional and Herbal Drugs

基　　金：国家中医临床研究基地科研专项(2021JDZX066);河南省中医药科学研究专项(2022ZY1043)。

摘　　要：炎症性肠病(inflammatory bowel disease,IBD)发病机制复杂,且在临床上表现出长期性、反复性的特点,对患者身心健康造成一定程度的不良影响。葛根Puerariae Lobatae Radix作为传统的药食同源中药,其化学成分多样,包括(异)黄酮类、有机酸类、萜类、香豆素类、甾体类及其他活性组分,具有解肌退热、升阳止泻等功效。现代药理学研究证实葛根及其有效成分在抗炎、抗氧化、调节免疫等多方面发挥治疗作用,对IBD的治疗具有多途径、多靶点的优势。新型复合材料的研发,有助于解决葛根素等活性成分口服生物利用度差等问题,使葛根在IBD的临床应用上获得更多可能。通过对近年来葛根及其有效成分治疗IBD的作用机制和应用进行综述,为葛根在IBD的临床使用提供一定参考。Inflammatory bowel disease(IBD)has a complex pathogenesis and often exhibits a long-term,recurrent pattern,which adversely affects patients’physical and mental health.Gegen(Puerariae Lobatae Radix),a traditional herb with medicinal and edible properties,has diverse chemical components,including(iso)flavonoids,organic acids,terpenes,coumarins,steroids,and other active components,which have functions such as relieving muscle spasms,reducing fever,promoting yang,and stopping diarrhea.Modern pharmacological studies have confirmed that Puerariae Lobatae Radix and its active components exert therapeutic effects in anti-inflammation,antioxidation,and immune regulation,which provide multi-pathway and multi-target therapeutic advantages in the treatment of IBD.The development of novel composite materials can help solve the problem of poor oral bioavailability of active components such as puerarin,which can increase the potential for the clinical application of Puerariae Lobatae Radix in IBD.This review summarizes the recent advances in treatment of IBD with Puerariae Lobatae Radix and its active components,and discusses their mechanisms of action and applications,with the aim of providing a reference for the clinical use of Puerariae Lobatae Radix in IBD.

关 键 词：葛根 葛根素 炎症性肠病 溃疡性结肠炎 克罗恩病 

分 类 号：R285[医药卫生—中药学]