枸杞多糖结构特征、生物活性及其降解研究进展  

Research progress on structural characteristics,biological activities and degradation of Lycium barbarum polysaccharides

作　　者：刘思 宋娟 洋雯茜 郑颖 陈晓娟 马百平 LIU Si;SONG Juan;YANG Wenxi;ZHENG Ying;CHEN Xiaojuan;MA Baiping(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]军事科学院军事医学研究院,北京100850

出　　处：《中草药》2025年第4期1440-1455,共16页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82274068)。

摘　　要：枸杞多糖(Lycium barbarum polysaccharides,LBPs)是枸杞子的重要活性成分之一,具有免疫调节、神经保护、抗肿瘤、抗辐射等生物活性,在药物和功能食品研发等领域具有良好应用前景。而多糖结构复杂,构效关系尚未明晰,通过研究低相对分子质量化、均一化的多糖降解产物的生物活性,可以有效挖掘多糖活性结构域。基于此,通过总结LBPs提取分离方法、结构特征及其生物活性,并综述了多糖降解方法及LBPs降解的研究进展,为LBPs的构效关系研究及其进一步开发提供理论依据。Lycium barbarum polysaccharides(LBPs),as one of the significant bioactive constituents of Gouqizi(Lycium barbarum),possess multiple biological activities such as immunomodulation,neuroprotection,antitumor,and radioprotective effects.It was reported to have promising application prospects in the domains of drug research and development as well as functional food exploitation.The structure-activity relationship of LBPs has not been clearly elucidated due to the structural complexity.Uncovering the bioactive polysaccharide domains can be achieved through investigating the biological activities of the low-molecular-weight and homogeneous degradative products of polysaccharides.To provide the basis for further research of the structure-activity relationship of LBPs,the extraction,separation and purification methods,structural features,and biological activities of LBPs were summarized,and the advance in depolymerization methods of polysaccharides as well as the degradation of LBPs was also reviewed in this paper.

关 键 词：枸杞多糖 提取分离 多糖降解 寡糖 免疫调节 神经保护 抗肿瘤 抗辐射 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]