益生菌辅助治疗对H型高血压患者临床指标改善及肠道微生态的影响分析  

Analysis of the impact of probiotic adjunctive treatment on clinical indicators and gut microecology in patients with H-type hypertension

作　　者：宋春颖 曹煜[2] SONG Chunying;CAO Yu(Key Laboratory of Environmental Pollution and Disease Control,School of Public Health and Health,Guizhou Medical University,Ministry of Education,Guiyang 561l13,China;Big Health Research Institute of Guizhou Medical University,Guiyang 561l13,China)

机构地区：[1]贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室,贵州贵阳561113 [2]贵州医科大学大健康研究院大健康研究院,贵州贵阳561113

出　　处：《中国病原生物学杂志》2025年第4期428-433,共6页Journal of Pathogen Biology

基　　金：贵阳市科协项目(No.SKX2023JCZX)。

摘　　要：目的本研究旨在探讨益生菌辅助治疗对H型高血压患者临床指标改善及肠道微生态的影响。方法通过对H型高血压患者进行益生菌辅助治疗与常规治疗的比较分析,评估了治疗前后的血压变化、脂质代谢相关指标(包括同型半胱氨酸Hcy、脂联素指数LAP和甘油三酯-葡萄糖指数TyG)以及肠道菌群的变化。结果治疗前,对照组和益生菌治疗组的收缩压和舒张压均值分别为139.89±3.11mmHg/90.08±1.99mmHg和140.13±3.25mmHg/89.97±1.99mmHg,两组间差异无统计学意义(P>0.05)。治疗后,对照组的收缩压和舒张压分别降至137.99±3.70 mmHg和88.18±2.52mmHg,而益生菌治疗组显著降至131.94±2.61mmHg和82.03±2.01mmHg(P<0.001)。益生菌治疗组在治疗后收缩压和舒张压的下降幅度均大于对照组(P<0.001)。在脂质代谢指标方面,益生菌治疗组的Hcy水平从15.05±1.43μmol/L降至11.99±0.83μmol/L,对照组从15.05±1.43μmol/L降至13.93±0.82μmol/L(P<0.001)。LAP指数和TyG指数在益生菌治疗组也有显著下降(P<0.001)。肠道菌群分析显示,益生菌治疗增加了有益菌如双歧杆菌科、乳杆菌科的相对丰度,同时降低了潜在有害菌属如肠杆菌科、链球菌科的相对丰度。益生菌治疗还提高了肠道菌群的多样性和均匀度,益生菌组的Shannon指数显著高于对照组,Simpson指数显著低于对照组(P<0.001)。结论益生菌辅助治疗能够显著改善H型高血压患者的血压控制和脂质代谢指标,并对肠道微生态产生积极影响。这些结果支持益生菌作为H型高血压患者辅助治疗手段的潜在价值。Objective This study aims to investigate the effects of probiotics as an adjunct therapy on the improvement of clinical indicators and intestinal microbiota in patients with H-type hypertension.Methods By comparing probiotic adjunct therapy with conventional treatment in patients with H-type hypertension,changes in blood pressure,lipid metabolism-related indicators(including homocysteine Hcy,lipopolysaccharide index LAP,and triglyceride glucose index TyG),and intestinal flora were assessed before and after treatment.Results Before treatment,the mean systolic and diastolic blood pressures in the control group and the probiotic treatment group were 139.89±3.11 mmHg/90.08±1.99 mmHg and 140.13±3.25 mmHg/89.97±1.99 mmHg,respectively,with no statistically significant difference between the two groups(P>0.05).After treatment,the systolic and diastolic blood pressures in the control group decreased to 137.99±3.70 mmHg and 88.18±2.52 mmHg,while in the probiotic treatment group,they significantly decreased to 131.94±2.61 mmHg and 82.03±2.01 mmHg(P<0.001).The reduction in systolic and diastolic blood pressures in the probiotic treatment group was greater than that in the control group(P<0.001).In terms of lipid metabolism indicators,the Hcy level in the probiotic treatment group decreased from 15.05±1.43μmol/L to 11.99±0.83μmol/L,while in the control group,it decreased from 15.05±1.43μmol/L to 13.93±0.82μmol/L(P<0.001).The LAP index and TyG index also significantly decreased in the probiotic treatment group(P<0.001).Intestinal flora analysis showed that probiotic treatment increased the relative abundance of beneficial bacteria such as Bifidobacteriaceae and Lactobacillaceae,while reducing the relative abundance of potentially harmful bacterial families such as Enterobacteriaceae and Streptococcaceae.Probiotic treatment also improved the diversity and evenness of the intestinal flora,with the Shannon index in the probiotic group significantly higher than in the control group and the Simpson index significant

关 键 词：H型高血压 肠道微生态 血压控制 脂质代谢 

分 类 号：R544.1[医药卫生—心血管疾病]