带状疱疹患者血清8-OHDG、YKL-40、NRG-1表达与后遗神经痛的关系  

The relationship between serum 8-OHDG,YKL-40,NRG-1 expression and postherpetic neuralgia in patients with herpes zoster

作　　者：杨丹 杨静[1] 郑东明[1] YANG Dan;YANG Jing;ZHENG Dongming(The No.4 Department of Neurology,Shengjing Hospital Affiliated to China Medical University,Shenyang,Liaoning 110020,China)

机构地区：[1]中国医科大学附属盛京医院第四神经内科,辽宁沈阳110020

出　　处：《中国病原生物学杂志》2025年第4期450-454,共5页Journal of Pathogen Biology

摘　　要：目的探究带状疱疹患者血清8-羟基脱氧鸟苷(8-OHDG)、人软骨糖蛋白-39(YKL-40)、神经调节蛋白1(NRG-1)表达与后遗神经痛(PHN)的关系。方法选取本院2019年1月~2023年12月收治的带状疱疹患者79例作为疾病组,根据治疗后随访90d,以患者是否发生PHN分为发生组(n=31)、未发生组(n=48);另选取同期50例在本院体检的健康者作为对照组。用ELISA法检测血清8-OHDG、YKL-40、NRG-1表达水平;用Spearson法分析患者血清8-OHDG、YKL-40、NRG-1水平与疼痛程度的相关性;ROC曲线分析血清8-OHDG、YKL-40、NRG-1对带状疱疹患者发生PHN的预测价值。结果疾病组血清8-OHDG、YKL-40明显高于对照组,血清NRG-1表达水平明显低于对照组(P<0.05)。发生组疱疹类型中出血型占比、视觉模拟(VAS)评分、血清8-OHDG、YKL-40水平明显高于未发生组,血清NRG-1水平低于未发生组(均P<0.05)。经Spearson法相关性分析显示,患者血清8-OHDG、YKL-40水平与VAS评分呈显著正相关,而血清NRG-1水平与VAS评分呈显著负相关(P<0.05)。血清8-OHDG、YKL-40、NRG-1联合预测带状疱疹患者发生PHN的曲线下面积(AUC)为0.957,优于各自单独检测(Z_(三者联合-8-OHDG)=2.697、Z_(三者联合-YKL-40)=2.748、Z_(三者联合-NRG-1)=2.849,P=0.007、P=0.006、P=0.004),其敏感度和特异度分别为90.32%、89.58%。结论带状疱疹患者血清8-OHDG、YKL-40水平明显升高,而血清NRG-1表达水平明显降低,三者联合检测对带状疱疹患者发生PHN有更高的预测价值,对改善带状疱疹患者预后有一定的指导意义。Objective Toinvestigate discusstht erelationshibpetween theexpression of serum 8-hydroxydeoxyguanosine(8-OHDG),human cartilage glycoprotein-39(YKL-40),and neurogulin-1(NRG-1)and postherpetic neuralgia(PHN)in patients with herpes zoster.Methods From January 2019 to December 2023,79 patients with herpes zoster admitted to our hospital were designated regarded as the disease group.According toComplying with a 90-day follow-up after treatment,the patients were assigned into an occurrence group(n=31)and a non occurrence group(n=48)based on whether they developed PHN.Meantime,another 50 healthy individuals who underwent physical examines examinations at our hospital were designated included as the control group.ELISA method was applied to detect the expression levels of serum 8-OHDG,YKL-40,and NRG-1.Spearson method was applied to analyze the correlation between serum levels of 8-OHDG,YKL-40,NRG-1 and pain severity in patients.ROC curve was applied to analyze the predictive value of serum 8-OHDG,YKL-40,and NRG-1 for the occurrence of PHN in patients with herpes zoster.Results The serum levels of 8-OHDG and YKL-40 in the disease group were had obviously higher serum 8-OHDG and YKL-4O than those in the control group,and prominently lower the expression level of serum NRG-1 was prominently lower than that in the control group(P<0.05).The occurrence group had prominently higher proportion of hemorrhagic typehemorrhagic herpes,visual analogue scale(VAS)score,serum 8-OHDG,YKL-40 levels in the occurrence group were prominently higher than those in the non occurrence group,and lower serum NRG-1 level was lower than those in the non occurrence group(all P<o.05).According toComplying with the Spearson correlation analysis,the levels of serum 8-OHDG and YKL-40 in patients were obviously positively correlated with related to VAS score,while the level of serum NRG-1 was obviously negatively crelated to orrelated with VAS score(P<0.05).The area under the curve(AUC)of the combination of serum 8-OHDG,YKL-4O,and NRG-1 for predicting PHN

关 键 词：8-羟基脱氧鸟苷 人软骨糖蛋白-39 神经调节蛋白1 带状疱疹 后遗神经痛 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]