重症急性胰腺炎合并真菌感染的临床诊治研究进展  

Progress in clinical diagnosis and treatment of severe acute pancreatitis complicated with fungal infection

作　　者：王彦霞 WANG Yanxia(Ulanqab Medical College,Wulanchabu 012000,Neimenggu,China)

机构地区：[1]乌兰察布医学高等专科学校,内蒙古乌兰察布012000

出　　处：《中国病原生物学杂志》2025年第4期526-529,533,共5页Journal of Pathogen Biology

摘　　要：重症胰腺炎(SAP)是临床严重疾病,其易合并真菌感染。真菌感染会加重SAP病情,增加诊治难度。鉴于此,结合国内外研究报道,旨在综述SAP合并真菌感染的临床诊治研究进展。梳理研究结果显示,SAP真菌感染发病率、死亡率较高,且风险因素良多。发病机制主要是机体免疫力低下、侵入性操作、抗生素长期应用、中性粒细胞下降所致。SAP真菌感染病原体主要以白色念珠菌、热带念珠菌、光滑念珠菌为主,诊断病原体的方法为直接镜检法、血清检测法、真菌培养法、分子生物学检测法、组织病理性检测法。手术、药物、支持等治疗方法能有效治疗真菌感染,但在SAP真菌感染中治疗研究较少。对上述内容进行深入分析能为SAP真菌感染的临床诊治方案制定提供依据。Severe pancreatitis(SAP)is a serious clinical disease,which is easy to be complicated with fungal infection.Fungal infection will aggravate the condition of SAP and increase the difficulty of diagnosis and treatment.In view of this,combined with domestic and foreign research reports,this paper aims to summarize the clinical diagnosis and treatment of SAP complicated with fungal infection.The results of combing research show that the incidence and mortality of fungal infection in SAP are high,and there are many risk factors.The pathogenesis is mainly caused by low immunity,invasive operation,long-term use of antibiotics and neutropenia.The main pathogens of fungal infection in SAP are Candida albicans,Candida tropicalis and Candida glabrata,and the methods for diagnosing pathogens are direct microscopic examination,serum detection,fungal culture,molecular biological detection and histopathological detection.Surgery,drugs,support and other treatments can effectively treat fungal infections,but there are few studies on the treatment of fungal infections in SAP.In-depth analysis of the above contents can provide basis for the clinical diagnosis and treatment of SAP fungal infection.

关 键 词：重症急性胰腺炎 真菌感染 临床诊治 综述 

分 类 号：R57[医药卫生—消化系统]