急性肾盂肾炎发病机制及诊治进展  

Pathogenesis,diagnosis and treatment progress of acute pyelonephritis

作　　者：刘梅[1] LIU Mei(Dazhou Vocational and Technical College,Dazhou 635000,Sichuan,China)

机构地区：[1]达州职业技术学院,四川达州635000

出　　处：《中国病原生物学杂志》2025年第4期530-533,共4页Journal of Pathogen Biology

摘　　要：本文深入探讨了急性肾盂肾炎的病因、发病机制、诊断方法以及诊治进展与未来方向。急性肾盂肾炎是常见的泌尿系统感染性疾病,其病因包括微生物感染、尿路解剖结构异常、免疫系统功能障碍和医源性因素等。发病机制主要涉及致病菌释放毒力因子与Toll受体结合,激活细胞信号通路,引发肾脏炎症反应。诊断依赖临床症状、实验室检查及影像学检查。在治疗方面,面临耐药性挑战和新型抗生素的研发。This article deeply discusses the etiology,pathogenesis,diagnostic methods,diagnosis and treatment progress and future directions of acute pyelonephritis.Acute pyelonephritis is a common infectious disease of the urinary system.Its etiologies include microbial infection,abnormal urinary tract anatomy,immune system dysfunction and iatrogenic factors.The pathogenesis mainly involves the combination of virulence factors released by pathogenic bacteria and Toll receptors,activating cell signaling pathways and triggering renal inflammatory responses.Diagnosis depends on clinical symptoms,laboratory tests and imaging examinations.In terms of treatment progress,the research and development of new antibiotics face the challenge of drug resistance.

关 键 词：急性肾盂肾炎 病因 发病机制 诊治 综述 

分 类 号：R69[医药卫生—泌尿科学]