铁死亡在金黄色葡萄球菌感染中的研究进展  

Recent Developments in Ferroptosis in Staphylococcus aureus Infections

作　　者：张轩 闫文通 王波 唐源 李日成 李军良[2] 潘海邦[1] ZHANG Xuan;YAN Wentong;WANG Bo;TANG Yuan;Li Richeng;LI Junliang;PAN Haibang(Gansu University of Traditional Chinese Medicine,First Clinical College,Lanzhou 730000,China;Gansu Provincial People's Hospital;Gansu University of Traditional Chinese Medicine,School of Nursing)

机构地区：[1]甘肃中医药大学第一临床学院普外科,甘肃兰州730000 [2]甘肃省人民医院普外科 [3]甘肃中医药大学护理学院普外科

出　　处：《中国病原生物学杂志》2025年第4期538-543,共6页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.81860850);敦煌医学与转化教育部重点实验室开放课题(No.DHYX22-02);甘肃省高等学校创新基金项目(No.2023S-76)。

摘　　要：金黄色葡萄球菌(Staphylococcus aureus,SA)感染是临床上最为常见疾病,也是引起细菌耐药最多的菌株。随着抗生素的广泛使用,SA耐药率逐年上升,使抗SA治疗面临严峻挑战。铁死亡是一种新发现的程序性细胞死亡方式,在细菌感染中扮演重要角色。本文通过从SA感染对宿主铁代谢的影响、铁死亡与免疫的关系、以及铁死亡与SA感染的机制和相关感染性疾病的关系进行梳理,以期为理解金黄色葡萄球菌感染的潜在机制提供了基础理论依据,同时为抗感染及抗菌药物研发提供新的思路和方向。Staphylococcus aureus(S.aureus)infection stands out as a prevalent clinical condition and a primary driver of bacterial drug resistance.The widespread utilization of antibiotics has led to a progressive rise in S.aureus resistance rates,presenting a notable hurdle to effective therapeutic strategies.Ferroptosis,an emerging form of programmed cell death,assumes a critical role in bacterial infections.This review delves into the repercussions of S.aureus infection on host iron metabolism,the intricate interplay between ferroptosis and immunity,and the mechanisms underlying the involvement of ferroptosis in S.aureus infection and associated infectious conditions.The objective is to establish a foundational comprehension of the underlying mechanisms of S.aureus infection and to unveil novel perspectives for the advancement of anti-infective and antimicrobial treatments.

关 键 词：金黄色葡萄球菌 铁死亡 致病机制 综述 

分 类 号：R378.1[医药卫生—病原生物学]