寄生虫感染中参与宿主巨噬细胞极化的信号通路研究进展  

Research progress on signaling pathways involved in host macrophage polarization during parasitic infections

作　　者：熊海婷 周必英 XIONG Haiting;ZHOU Biying(Department of Parasitology,School of Basic Medicine,Zunyi Medical University,Zunyi 563000,Guizhou,China)

机构地区：[1]遵义医科大学基础医学院寄生虫学教研室,贵州遵义563000

出　　处：《中国病原生物学杂志》2025年第4期544-548,F0004,共6页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.82460402、No.81960378)。

摘　　要：巨噬细胞是重要的固有免疫细胞和抗原提呈细胞,在机体感染与免疫中发挥着重要的作用。巨噬细胞具有可塑性和异质性,微环境的改变可使巨噬细胞发生极化,主要分为经典活化型(M1型)和替代活化型(M2型)巨噬细胞,M1型巨噬细胞可促进机体炎症反应,在炎症早期发挥抗感染作用;M2型巨噬细胞可抑制炎症反应,在炎症后期与组织修复相关。本文就寄生虫感染中调控宿主巨噬细胞极化相关信号通路的研究进展进行综述。Macrophages are important innate immune cells and antigen-presenting cells,playingacrucial role in infection andimmunityin the body.Macrophages exhibit plasticity and heterogeneity,and alterations in the microenvironment can induce polarization.They are primarily categorized into classically activated(Mi)and alternatively activated(M2)macrophages.M1 macrophages facilitate the body's inflammatory response and serve an anti-infective role in the early stages of inflammation,while M2 macrophages suppress inflammatory reactions and are linked to tissue repair in the later stages of inflammation.This article provides a review of the progress in research on the signal pathways related to the regulation of host macrophage polarization in parasitic infections.

关 键 词：寄生虫 巨噬细胞极化 信号通路 综述 

分 类 号：R392[医药卫生—免疫学]