酰基辅酶A合成酶短链家族成员2(ACSS2)的研究进展  

Research progress of acyl-CoA synthetase short-chain family member 2 protein

作　　者：李瑞雪 吴思雨 曹锟 刘新光 LI Ruixue;WU Siyu;CAO Kun;LIU Xinguang(Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics,Institute of Aging Research,Institute of Biochemistry&Molecular Biology,Guangdong Medical University,Dongguan 523808,China;School of Medical Technology,Guangdong Medical University,Dongguan 523808,China;Talent Development Foundation of the First Dongguan Affiliated Hospital of Guangdong Medical University&Foundation of State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Dongguan 523808,China)

机构地区：[1]广东医科大学广东省医学免疫与分子诊断重点实验室,衰老研究所,生物化学与分子生物学研究所,东莞523808 [2]广东医科大学医学技术学院,东莞523808 [3]广东医科大学附属东莞第一医院,省部共建中亚高发病成因与防治国家重点实验室,东莞523808

出　　处：《生命的化学》2025年第2期223-230,共8页Chemistry of Life

基　　金：国家自然科学基金项目(81971329,81671399);广东省自然科学基金面上项目(2022A1515010191,2024A1515012465,2024A1515012922);广东省普通高校重点领域专项(2022ZDZX2023);广东医科大学附属东莞第一医院英才计划省部共建中亚高发病成因与防治国家重点实验室广东联合基金项目(SKL-HIDCA-2024-GD8);广东省医学科研基金项目(B2024043)。

摘　　要：酰基辅酶A合成酶短链家族成员2(acyl-CoA synthetase short-chain family member 2,ACSS2)是一种参与脂肪酸代谢的酶,主要功能是在细胞中催化短链脂肪酸、辅酶A与乙酸反应并产生乙酰辅酶A,为细胞能量代谢提供重要碳源。ACSS2在蛋白质乙酰化、能量代谢和脂肪酸代谢过程中都具有重要的作用。本文系统地综述了ACSS2的生物学功能,阐述了ACSS2主要参与衰老与肿瘤相关疾病的分子机制和潜在治疗方案,为抗衰老和抗肿瘤研究提供新思路。Acyl-CoA synthetase short-chain family member 2(ACSS2)is an enzyme involved in cellular fatty acid metabolism that catalyzes short chain fatty acids,CoA,and acetic acid to produce acetyl-CoA.It provides an important carbon source for cell energy metabolism.ACSS2 plays a crucial role in various biological processes such as protein acetylation,energy metabolism and fatty acid metabolism.This paper systematically reviewed the biological functions of ACSS2,elucidated the molecular mechanisms and potential therapeutic strategies of ACSS2 involvement in aging and tumor related diseases,and provided new insights for anti-aging and anti-tumor research.

关 键 词：酰基辅酶A合成酶短链家族成员2 乙酰辅酶A 衰老 肿瘤 代谢 乙酰化 

分 类 号：R28[医药卫生—中药学]