AMPK信号通路与2型糖尿病合并帕金森病的相关性及中药干预作用  

Correlation between AMPK signaling pathway and type 2 diabetes mellitus complicated with Parkinson's disease and the intervention effect of Chinese medicine

作　　者：刘宗州 姬琳[2] 张明庆[2] 王学斌[2] 王缓缓 刘小琳 王兴臣[2] LIU Zongzhou;JI Lin;ZHANG Mingqing;WANG Xuebin;WANG Huanhuan;LIU Xiaolin;WANG Xingchena(The First Clinical School of Shandong University of Traditional Chinese Medicine,Ji'nan 250014,China;Department of Encephalopathy,Shandong University of Traditional Chinese Medicine Second Affiliated Hospital,Ji'nan 250001,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250014 [2]山东中医药大学第二附属医院脑病科,济南250001

出　　处：《生命的化学》2025年第2期309-323,共15页Chemistry of Life

基　　金：全国名老中医专家传承工作室建设项目(国中医药人教函[2022]75号);齐鲁扁仓中医药人才培育项目(鲁卫函[2024]78号);山东省中医药科技项目(2020M021);山东省中医药科技项目(2021Q099);山东省医药卫生科技发展计划项目(202003070825)。

摘　　要：随着大脑中胰岛素异常信号与神经退行性病变关系的发现,2型糖尿病(type 2 diabetes mellitus,T2DM)和帕金森病(Parkinson's disease,PD)之间共同致病机制的研究越来越受到关注。既往研究表明,腺苷酸活化蛋白激酶(adenine monophosphate-activated protein kinase,AMPK)在T2DM和PD之间起到关键的作用。AMPK通过调节线粒体稳态、糖代谢、脂质代谢、蛋白质代谢、胰岛素抵抗、星形胶质细胞和血管损伤等直接或间接参与T2DM和PD发病。AMPK激动剂可以降低外周血中的血糖、血脂水平,缓解胰岛素抵抗从而减轻T2DM症状;它还通过保护神经元、清除α-突触核蛋白(α-synuclein,α-syn)预防PD发病和控制PD病情。近年来,中药调控AMPK信号通路治疗PD的国内外研究日渐丰富,中药复方及中药有效成分通过干预和调节AMPK磷酸化、细胞能量代谢和线粒体稳态等方面有效改善了PD大脑神经退行性变,为PD的预防和治疗提供了新的治疗思路和策略。With the discovery of the relationship between abnormal insulin signaling and neurodegeneration in the brain,the study of the co-pathogenic mechanism between type 2 diabetes mellitus(T2DM)and Parkinson's disease(PD)has attracted more and more attention.Previous studies have shown that adenine monophosphate-activated protein kinase(AMPK)plays a critical role between T2DM and PD.AMPK is directly or indirectly involved in the pathogenesis of T2DM and PD by regulating mitochondrial homeostasis,glucose metabolism,lipid metabolism,protein metabolism,insulin resistance,astrocyte,and vascular injury.AMPK agonists can reduce blood glucose and lipid levels in peripheral blood,alleviate insulin resistance,and reduce T2DM symptoms.It also prevents the onset of PD and controls the onset of PD by protecting neurons and clearingα-synuclein(α-syn).In recent years,research on the regulation of AMPK signaling pathway by traditional Chinese medicine for treating PD has become increasingly abundant both domestically and internationally.Traditional Chinese medicine formulas and active ingredients effectively improve neurodegeneration in PD by intervening and regulating AMPK phosphorylation,cellular energy metabolism,and mitochondrial homeostasis,providing new treatment ideas and strategies for preventing and treating PD.Download(CAJ format)Download(PDF format)

关 键 词：AMPK 2型糖尿病 帕金森病 胰岛素抵抗 线粒体稳态 能量代谢 

分 类 号：R58[医药卫生—内分泌]