LCE3B_LCE3C缺失与内蒙古蒙古族寻常型银屑病的关联性研究  

Association Analysis Between LCE3B_LCE3C-Deletion and Psoriasis Vulgaris of Mongolian Nationality in Inner Mongolia Area

作　　者：曹玉婷 孙立[2] 纳贡毕利格 崔宏伟 韩建文[2] 李利仲 赵文超 CAO Yuting;SUN Li;Nargongbilige;CUI Hongwei;HAN Jianwen;LI Lizhong;ZHAO Wenchao(Department of Dermatology,Inner Mongolia Maternal and Child Health Care Hospital,Huhhot,Inner Mongolia 010000,China;Department of Dermatology,Affiliated Hospital of Inner Mongolia Medical University,Huhhot,Inner Mongolia 010000,China;Department of Psychosomatic Medicine,Inner Mongolia International Mongolian Medicine Hospital,Huhhot,Inner Mongolia 010000,China;Clinical Medical Research Center,Inner Mongolia Medical University,Huhhot,Inner Mongolia 010000,China;Department of Dermatology,Qingshuihe County Maternal and Child Health HosPital,Huhhot,Inner Mongolia 010000,China;Department of Mechanicidae,Inner Mongolia Blood Center,Huhhot,Inner Mongolia 010000,China)

机构地区：[1]内蒙古自治区妇幼保健院皮肤科,内蒙古呼和浩特010000 [2]内蒙古医科大学附属医院皮肤科,内蒙古呼和浩特010000 [3]内蒙古国际蒙医医院心身医学科,内蒙古呼和浩特010000 [4]内蒙古医科大学临床医学研究中心,内蒙古呼和浩特010000 [5]清水河县妇幼保健院皮肤科,内蒙古呼和浩特010000 [6]内蒙古血液中心机采科,内蒙古呼和浩特010000

出　　处：《中国医药指南》2025年第7期102-105,共4页Guide of China Medicine

摘　　要：目的 探讨晚期角质化包膜蛋白(LCE)3B_3C缺失与中国内蒙古地区蒙古族寻常型银屑病的关联性。方法 收集2005年1月至2018年12月内蒙古地区蒙古族寻常型银屑病患者305例(病例组),健康对照383例(对照组)。经知情同意后采集外周静脉血2 ml。选择位于LCE基因区域的LCE3B_LCE3C缺失进行基因分型检测。对比分析两个组别患者等位基因和基因型频率分布规律,按照相关公式计算得到相对危险度数值,估计数值的可信区间达到95%。在7个单核苷酸多态性(SNP)(rs6701216、rs4112788、rs12023196、rs512208、rs4845454、rs4085613、rs1886734)与LCE3B_LCE3C缺失间进行连锁不平衡检验,分别计算两两间的R2值及D值。结果 本研究中检测的LCE3B_LCE3C缺失在病例组及对照组中的等位基因频率分别为67.54%和50.91%,差异有统计学意义(P <0.05)。基因型分析结果显示,LCE3B_LCE3C缺失纯合子在病例组中的分布频率高于对照组(P <0.05)。连锁不平衡分析结果显示,rs4112788与LCE3C_LCE3B缺失、rs4845454与LCE3C_LCE3B缺失以及rs4085613与LCE3C_LCE3B缺失间存在强连锁不平衡。结论 LCE3B_LCE3C缺失与内蒙古地区蒙古族寻常型银屑病具有相关性。Objective To investigate the association between late keratinized envelope protein(LCE)3B_3C deletion and psoriasis vulgaris of Mongolian people in Inner Mongolia,China.Methods A total of 305 Mongolian patients with psoriasis vulgaris(case group)and 383 healthy controls(control group)were collected from January 2005 to December 2018 in Inner Mongolia.2 ml of peripheral venous blood was collected after informed consent.The deletion of LCE3B_LCE3C in the LCE gene region was selected for genotyping.The frequency distribution of alleles and genotypes in the two groups was compared and analyzed,and the relative risk value was calculated according to the correlation formula,and the confidence interval of the estimated value was 95%.Linkage disequilibrium test was performed between seven single nucleotide polymorphisms(SNP)(rs6701216,rs4112788,rs12023196,rs512208,rs4845454,rs4085613,rs1886734)and LCE3B_LCE3C deletion.The R2 and D values of the two rooms are calculated respectively.Results In this study,the allele frequencies of LCE3B_LCE3C deletion detected in the case group and the control group were 67.54%and 50.91%,respectively,with statistical significance(P<0.05).Genotype analysis showed that the distribution frequency of LCE3B_LCE3C deletion homozygotes in the case group was higher than that in the control group(P<0.05).The results of linkage disequilibrium analysis showed that there was strong linkage disequilibrium between rs4112788 and LCE3C_LCE3B,rs4845454 and LCE3C_LCE3B,and rs4085613 and LCE3C_LCE3B.Conclusions The LCE3B_LCE3C-deletion was associated with psoriasis vulgaris of Mongolian nationality in Inner Mongolia area.

关 键 词：蒙古族 银屑病 LCE3B_LCE3C缺失 关联性研究 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]