1例兔球虫与奇异变形杆菌混合感染病例的诊断与治疗  

Diagnosis and Treatment of a Case of Mixed Infection of Rabbit Coccidiosis and Proteus mirabilis

作　　者：曹禹 李烨 尹珺伊 刘秋瑾 白长胜 王欢 田秋丰 CAO Yu;LI Ye;YIN Junyi;LIU Qiujin;BAI Changsheng;WANG Huan;TIAN Qiufeng(Heilongjiang Academy of Agricultural Sciences Branch of Animal Husbandry and Veterinary Branch,Qiqihar Heilongjiang 161005,China;Heilongjiang Key Laboratory of Veterinary Drugs,Qiqihar Heilongjiang 161005,China)

机构地区：[1]黑龙江省农业科学院畜牧兽医分院,黑龙江齐齐哈尔161005 [2]黑龙江省兽用药物重点实验室,黑龙江齐齐哈尔161005

出　　处：《现代畜牧科技》2025年第2期17-20,共4页Modern Animal Husbandry Science & Technology

基　　金：黑龙江省农业科技创新跨越工程农业科技基础创新优青项目(CX23BS06)。

摘　　要：为明确引起齐齐哈尔地区某兔养殖企业出现大量兔死亡原因,试验采用临床剖检、寄生虫分离鉴定方法和细菌分离鉴定方法对病原进行研究。结果表明,病死兔出现严重腹泻症状,肠道胀气,肠系膜水肿充血;肝脏呈暗红色,质地变硬,边缘锐利,可见明显的坏死;排泄物中发现大量球虫卵囊。将球虫卵囊孢子化培养后在显微镜下共观察到6种形态特征不一致的球虫卵囊。病原菌为奇异变形杆菌,该菌株对常用药物均有耐药性。说明造成齐齐哈尔某养兔场发生严重腹泻和大批死亡的病因为6种球虫混合感染后继发异变形杆菌促进病情发展,引起大批兔死亡。In order to determine the cause of a large number of rabbit deaths in a rabbit breeding enterprise in Qiqihar,clinical necropsy,parasite isolation and identification methods,and bacterial isolation and identification methods were used to study the pathogens.The results showed that the dead rabbits exhibited severe diarrhea symptoms,intestinal bloating,and mesenteric edema with congestion;the liver was dark red,hard in texture,sharp-edged,and had obvious necrosis;a large number of coccidian oocysts were found in the excrement.After sporulation and cultivation of the coccidian oocysts,six types of oocysts with inconsistent morphological characteristics were observed under a microscope.The pathogenic bacteria were identified as Proteus mirabilis,and this strain was resistant to commonly used drugs.It is concluded that the cause of the severe diarrhea and mass deaths in a rabbit breeding farm in Qiqihar was due to mixed infections with six types of coccidia,followed by secondary infection with Proteus mirabilis,which promoted the progression of the disease and led to a large number of rabbit deaths.

关 键 词：兔 球虫 奇异变形杆菌 病原分离鉴定 

分 类 号：S858.291[农业科学—临床兽医学]