黄芪-丹参药对防治心血管疾病的研究进展  

Research progress on the drug pair of Astragalus membranaceus-Salvia miltiorrhiza in preventing and treating cardiovascular diseases

作　　者：于小刚 辛二旦 卢玉俊[2,3] 代晶晶 马程 董建斌 姜佳辰 王庆胜 

机构地区：[1]甘肃省中医院,甘肃兰州730050 [2]甘肃中医药大学,甘肃兰州730099 [3]甘肃中医药大学附属医院,甘肃兰州730099

出　　处：《华西药学杂志》2025年第1期105-109,共5页West China Journal of Pharmaceutical Sciences

基　　金：国家重点研发计划(2018YFC1705600;2018YFC1705604);国家中医药管理局资助项目(国中医药人教函[2022]239号);甘肃省中医药研究中心2020年专项开放课题(zyzx-2020-zx25);甘肃省名中医传承工作室建设项目(甘中医药发[2024]7号);甘肃省中医药科研课题(GZKG-2024-48);甘肃中医药大学附属医院科研及技术创新基金(gzfy-2021-09)。

摘　　要：黄芪-丹参药对的主要成分包括皂苷类、有机酸类、黄酮类、醌类等化合物,具有降低心肌纤维化、抑制心室重构、减轻心肌细胞凋亡和损伤、减轻心肌炎性反应、抑制心肌细胞收缩、减慢心率、促进心脏新生血管的生成、调节心肌细胞能量代谢、调节血脂代谢、参与血压调节等作用。现综述黄芪-丹参药对防治心血管疾病的作用及机制,以期为临床安全合理用药及新药研发提供参考。The principal components of the Astragalus membranaceus-Salvia miltiorrhiza pair(ASP) include saponins, organic acids, flavonoids, and quinones, which possess various effects including the reduction of myocardial fibrosis, the inhibition of ventricular remodeling, the alleviation of myocardial cell apoptosis and damage, and so forth. The components of ASP have been observed to attenuate myocardial inflammatory reactions, inhibit myocardial cell contraction, slow heart rate, promote the generation of new blood vessels in the heart, regulate myocardial cell energy metabolism and lipid metabolism, and participate in blood pressure regulation. This article reviews the role and mechanisms of ASP in preventing and treating cardiovascular diseases based on literature research, aiming to provide a reference for the safe and rational clinical use of drugs, as well as for the development of new drugs.

关 键 词：黄芪 丹参 药对 心血管疾病 作用机制 研究进展 

分 类 号：R96[医药卫生—药理学]