Effects on the receptivity of thin endometrium treated with acupuncture therapy for menstruation regulation and pregnancy promotion:A pragmatic randomized controlled exploratory study  

调经促孕针刺法对薄型子宫内膜容受性影响的实用性随机对照探索试验

作　　者：Chen-si ZHENG Hui-sheng YANG Ming-zhao HAO Si-yu LIU Yi-gong FANG 郑晨思;杨会生;郝鸣昭;刘思雨;房繄恭(中国中医科学院针灸研究所,北京100700;深圳市妇幼保健院针灸推拿科,深圳518000)

机构地区：[1]Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China [2]Department of Acupuncture and Moxibustion and Tuina,Shenzhen Maternity&Child Healthcare Hospital,Shenzhen 518000,China

出　　处：《World Journal of Acupuncture-Moxibustion》2025年第1期50-57,共8页世界针灸杂志(英文版)

基　　金：Supported by Special Funds for Basic Scientific Research of Central Public Welfare Research Institutes:201814006。

摘　　要：Objective:This study aimed to explore the clinical effect of acupuncture therapy for menstruation regu-lation and pregnancy promotion on thin endometrium in the real world.Design:This study is a single-center pragmatic randomized controlled trial blinded to the statisticians.Using the“blockrand”software package,based on the age(≥35,<35),37 patients were randomized into an intervention group(19 cases)and a control group(18 cases).After reassignment regarding patient preference,21 patients were included in the intervention group and 16 in the control group.Setting:The trial was executed in the Specialty Outpatient Clinic,Acupuncture-Moxibustion Hospital of China Academy of Chinese Medical Sciences,from March 1,2019,to September 30,2020.Participants:The study included 37 patients with thin endometrium and without previous acupuncture treatment.Intervention:The intervention group was administered acupuncture for menstruation regulation and pregnancy promotion and a small-dose of progynova(2 mg daily),while the control group was adminis-tered a large-dose of progynova(4 mg daily).Interventions started from Day 5 of menstruation until the end of ovulation under B-ultrasound monitoring.The intervention lasted for three menstrual cycles.Measurements:Primary outcomes were changes in endometrial thickness between baseline and after intervention completion and the difference between the two groups after intervention.The secondary outcomes were endometrial and subendometrial blood flow,serum estradiol levels,menstrual conditions,and adverse reactions.Results:(1)Comparison of each indicator before and after intervention completion in the two groups:in the intervention group,the differences were significant in endometrial thickness,menstrual score,estra-diol(E2)level in ovulatory period,the pulsatility index(PI)and resistance index(RI)of uterine artery,the ratio of peak systolic velocity to end-diastolic velocity(S/D),the endometrial vascular index(VI),flow index(FI),and vascular flow index(VFI)and volume(P<0.01).In the

关 键 词：RECEPTIVITY Thin endometrium Acupuncture Menstruation regulation and pregnancy promotion 

分 类 号：R24[医药卫生—中医临床基础]