纳米银敷料抗菌性能评价研究  

Evaluation of Antibacterial Performance of Nano Silver Dressings

作　　者：栾同青 方良艳 李春巧 乔云倩 王文庆 Luan Tongqing;Fang Liangyan;Li Chunqiao;Qiao Yunqian;Wang Wenqing(Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection,NMPA Key Laboratory for Quality Evaluation of Medical Materials and Biological Protective Devices,Ji’nan 250101,China)

机构地区：[1]山东省医疗器械和药品包装检验研究院国家药品监督管理局医用卫生材料及生物防护器械质量评价重点实验室,济南250101

出　　处：《中国药事》2025年第2期160-164,共5页Chinese Pharmaceutical Affairs

基　　金：十四五国家重点研发计划“应用纳米材料医疗器械的风险评价关键技术及其标准化研究”(编号2022YFC2409704)。

摘　　要：目的:评价纳米银敷料的抗菌性能。方法:本研究将适量菌液接种于不影响微生物生长的无菌玻璃薄片上,采用直接覆盖的方式,将经恒温恒湿处理的纳米银敷料覆盖于菌液之上,并确保无溢出,接触一定时间后,将玻璃薄片及敷料合并洗脱计数。同时,采用常规的吸收法和振荡法进行对比评价。结果:采用本研究方法,试验样品在24 h后,对金黄色葡萄球菌、大肠杆菌和白色念珠菌的抗菌率对数值均> 3.00,均高于常规的吸收法和振荡法的测定结果。结论:该方法可有效应用于具有疏水性和缓释性特征的纳米银敷料的抗菌性能评价。Objective:To evaluate the antibacterial performance of nano silver dressings.Methods:In this study,an appropriate amount of bacterial solution was inoculated onto sterile glass sheets that did not affect microbial growth.The nano silver dressings treated with constant temperature and humidity was directly covered on top of the bacterial solution with no overflow ensured.After a certain period of contact,the glass sheets and dressing were combined for elution counting.Meanwhile,conventional absorption and oscillation methods are used for comparative evaluation.Results:Using the method of this study,the logarithmic values of the antibacterial rates of the test samples against Staphylococcus aureus,Escherichia coli,and Candida albicans were all greater than 3.00 after 24 hours,which were higher than the results obtained by conventional absorption and oscillation methods.Conclusion:This method can be effectively applied to evaluate the antibacterial performance of nano silver dressings with hydrophobic and sustained-release characteristics.

关 键 词：纳米银敷料 疏水性 缓释性 直接覆盖 抗菌性能 

分 类 号：R917[医药卫生—药物分析学]