镍催化2-氟吡啶参与的Suzuki偶联反应  

Nickel-catalyzed Suzuki coupling reaction of 2-fluoropyridines

作　　者：王子安 殷春雨 梅佳彤 张华 WANG Zian;YIN Chunyu;MEI Jiatong;ZHANG Hua(School of Chemistry and Materials Science,South-Central Minzu University,Wuhan 430074,China)

机构地区：[1]中南民族大学化学与材料科学学院,武汉430074

出　　处：《中南民族大学学报(自然科学版)》2025年第3期295-300,共6页Journal of South-Central Minzu University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(22271313,21602096)。

摘　　要：报道了一例镍催化2-氟吡啶化合物与芳基硼酸的Suzuki偶联反应,实现了2-芳基吡啶化合物的高效合成.该方法反应条件简单、原料易得、产率和官能团普适性良好,不同官能团取代的2-氟吡啶和芳基硼酸都易于发生反应得到2-芳基吡啶化合物.基于实验结果和相关文献报道推测了可能的反应机理.该反应不仅为2-芳基吡啶化合物的合成提供了新方法,而且为由吡啶骨架分子出发高选择性高产率获得2-芳基吡啶衍生物提供了可能.A nickel-catalyzed Suzuki coupling reaction between 2-fluoropyridines and arylboronic acids towards the efficient synthesis of 2-arylpyridines was reported.This method exhibited advantages including simple reaction conditions,easy availability of raw materials,good yield and functional group compatibility,in which 2-fluoropyridines and aryl boronic acids substituted with different functional groups reacted easily to produce 2-arylpyridines.Based on the experimental findings and literature,a reaction mechanism was postulated.This reaction not only offered a novel approach to the synthesis of 2-arylpyridines,but also provided the possibility for obtaining 2-arylpyridine derivatives from pyridine scaffold-containing molecules with high selectivity and high yield.

关 键 词：镍催化 2-氟吡啶 SUZUKI偶联 2-芳基吡啶 

分 类 号：O626.42[理学—有机化学]