叶状ZIF-L@Ag复合材料的合成、表征和抗菌性能  

Synthesis,characterization,and antibacterial properties of leaf-shaped ZIF-L@Ag composites

作　　者：徐建铭 戴乐 朱家骅 韩晓乐[1] XU Jianming;DAI Le;ZHU Jiahua;HAN Xiaole(College of Chemistry and Materials Science,South-Central Minzu University,Wuhan 430074,China)

机构地区：[1]中南民族大学化学与材料科学学院,武汉430074

出　　处：《中南民族大学学报(自然科学版)》2025年第3期301-306,共6页Journal of South-Central Minzu University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(32271538);中央高校基本科研业务费专项资金资助项目(GZY23005)。

摘　　要：ZIF系列是类沸石的咪唑酸盐框架材料.ZIF-L是Zn^(2+)与2-甲基咪唑的N原子配位后自组装形成的材料,具有良好的加载和吸附能力.通过水溶液合成方法,合成了叶状ZIF-L,并与Ag纳米颗粒(NPs)吸附结合,形成叶片状ZIF-L@Ag复合材料.通过最小抑制浓度(MIC)、CFU计数法分析,发现ZIF-L@Ag复合材料对耐碳青霉烯铜绿假单胞菌表现出了优异的抗菌性能.细胞膜通透性测定结果表明,ZIF-L@Ag NPs复合材料能够改变细菌细胞膜的通透性.The ZIF series represents a class of zeolite-like imidazolate frame material,with ZIF-L being characterized by self-assembly following the coordination of nitrogen atoms from 2-methylimidazole with Zn^(2+),thereby exhibiting notable loading and adsorption capabilities.The synthesis of leaf-shaped ZIF-L was presented via an aqueous solution approach,subsequently integrating it with silver nanoparticles(NPs)to form the foliated ZIF-L@Ag composite.Assessment through minimum inhibitory concentration(MIC)and colony-forming unit(CFU)counting analyses revealed the exceptional antibacterial efficacy of the ZIF-L@Ag composite against carbapenem-resistant Pseudomonas aeruginosa.The results of cell membrane permeability measurement indicated that ZIF-L@AgNPs composites could modulate the permeability of bacterial cell membranes.

关 键 词：ZIF-L咪唑酸盐框架材料 ZIF-L@Ag复合材料 抗菌材料 

分 类 号：O64[理学—物理化学]