日本脑炎疫苗研究现状  

Researh Status on Japanese Encephalitis Vaccines

作　　者：陈云蕾 张泽林 丁林玲 刘璐 程国华 甘凌峰 张鲲 张帅 CHEN Yun-lei;ZHANG Ze-lin;DING Lin-ling;LIU Lu;CHENG Guo-hua;GAN Lin-feng;ZHANG Kun;ZHANG Shuai(Management Center of Equine Disease Free Zone of Tonglu,Hangzhou,Zhejiang,310000,China;Department of Animal Science,Ganzhou polytechnic College,Ganzhou,Jiangxi,341000,China;College of Veterinary Medicine,Henan Agricultural University,Zhengzhou,Henan,450000,China)

机构地区：[1]浙江省杭州市桐庐县无规定马属动物疫病区管理中心,浙江杭州310000 [2]赣州职业技术学院动物科学系,江西赣州341000 [3]河南农业大学动物医学院,河南郑州450000

出　　处：《动物医学进展》2025年第3期119-124,共6页Progress In Veterinary Medicine

基　　金：杭州市农业与社会发展科研引导项目(20220919Y203);河南农业大学优秀研究生国内外联合培养基金;杭州市桐庐县511中青年人才培养工程项目。

摘　　要：日本脑炎(Japanese encephalitis,JE)是由日本脑炎病毒(JEV)引起的一种严重危害人类和多种动物健康的人兽共患传染病,目前尚无治疗JE的有效药物。疫苗免疫是降低人、猪、马等动物感染JEV的首选,当前JE疫苗研究迫切需要开发新的更为安全、有效的候选疫苗,解决现有疫苗对流行毒株的交叉保护率低及保护期短等问题。为更好地了解当前JE疫苗研究进展,论文从JEV分子病原学特征、疫苗应用现状等方面,总结JEV疫苗研发现状,以期为JE疫苗研发提供参考。Japanese encephalitis is a serious zoonotic infectious disease that poses a significant threat to both human and animal health.Currently,there is no effective treatment for JE,making vaccination the primary strategy for reducing JEV infection in humans,pigs,horses,and other animals.However,the urgent need persists for the development of new,safer,and more effective candidate vaccines to address issues such as low cross-protection rates against prevalent strains and short duration of protection associated with existing vaccines.To better understand the current status of JE vaccine research,this review summarizes recent advances in JE vaccine research,focusing on molecular pathogenesis characteristics and progress in vaccine applications,so as to provide insights for researchers and practitioners in the field.

关 键 词：日本脑炎病毒 疫苗免疫 分子病原学 交叉保护 

分 类 号：S828.9[农业科学—畜牧学]