经皮冠状动脉介入对冠心病合并左心功能不全患者的疗效分析  

Curative Effect of Percutaneous Coronary Intervention in Patients with Coronary Heart Disease Complicated with Left Ventricular Dysfunction

作　　者：汪明 张历 WANG Ming;ZHANG Li(Department of Cardiovascular Medicine,the Second Affiliated Hospital of Jiujiang University,Jiujiang 332000,China;Department of Cardiovascular Medicine,Jiujiang First People’s Hospital,Jiujiang 332000,China)

机构地区：[1]江西省九江学院第二附属医院心血管内科,江西九江332000 [2]江西省九江市第一人民医院心血管内科,江西九江332000

出　　处：《中国伤残医学》2024年第24期73-77,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探究经皮冠状动脉介入(PCI)治疗冠心病合并左心功能不全的效果。方法:回顾性分析2022年2月—2024年6月九江学院第二附属医院及九江市第一人民医院结束治疗的87例冠心病合并左心功能不全患者资料,按照治疗方法不同将其分为常规组(n=40)和介入组(n=47)。常规组采用常规药物治疗,介入组行PCI治疗。对比两组心功能指标、心脏舒张功能、心肌酶学指标及心功能分级。结果:术后5 d,介入组的左室舒张末期内径、左室收缩末期内径均小于常规组,左室射血分数大于常规组,差异均有统计学意义(P<0.05)。术后5 d,介入组的等容舒张时间短于对照组,二尖瓣舒张早期峰值血流速度/二尖瓣舒张晚期峰值血流速度比值大于对照组,差异均有统计学意义(P<0.05)。术后2周,介入组的N末端B型脑钠肽前体水平低于常规组,差异有统计学意义(P<0.05)。介入组的心功能分级情况优于常规组,差异有统计学意义(P<0.05)。结论:冠心病合并左心功能不全患者接受PCI治疗,能降低其N末端B型脑钠肽前体水平,改善其心功能指标,提升患者的心功能分级。Objective:To investigate the effect of percutaneous coronary intervention(PCI)in the treatment of coronary heart disease complicated with left heart dysfunction.Methods:The data of 87 patients with coronary heart disease complicated with left heart dysfunction who finished treatment in the Second Affiliated Hospital of Jiujiang University and Jiujiang First People’s Hospital from February 2022 to June 2024 were retrospectively analyzed,and were divided into the routine group(n=40)and the interventionization group(n=47)according to different treatment methods.The conventional group was treated with conventional drugs and the interventional group was treated with PCI.The ceardiac function indexes,diastolic function,myocardial enzyme index and cardiac function grade were compared between the two groups.Results:Five days after operation,the left ventricular end-diastolic diameter and left ventricular end-systolic diameter in the interventional group were smaller than those in the conventional group,and the left ventricular ejection fraction was larger than that in the conventional group,the differences were statistically significant(P<0.05).Five days after operation,the isovolumic relaxation time in the intervention group was shorter than that in the control group,and the ratio of mitral valve peak blood flow velocity in the early stage of mitral valve diastole to mitral valve peak blood flow velocity in the late stage of mitral valve diastole was greater than that in the control group,the differences were statistically significant(P<0.05).Two weeks after operation,the level of N-terminal pro-B-type natriuretic peptide in the interventional group was lower than that in the conventional group,and the difference was statistically significant(P<0.05).The cardiac function grading of the intervention group was better than that of the conventional group,and the difference was statistically significant(P<0.05).Conclusion:PCI can reduce the level of N-terminal pro-B-type natriuretic peptide,improve the cardiac function ind

关 键 词：冠心病 左心功能不全 经皮冠状动脉介入 心功能分级 N末端B型脑钠肽前体 

分 类 号：R541.4[医药卫生—心血管疾病]