急性心肌梗死患者血清GDF-15、Lp-PLA2、H-FABP水平与病情程度的相关性  

Correlation between serum GDF-15,Lp-PLA2,H-FABP levels and severity of acute myocardial infarction in patietns

作　　者：侯小莉 李双雁 任敏 HOU Xiaoli;LI Shuangyan;REN Min(Laboratory Department,Shaanxi Province Mianxian Hospital,Hanzhong 724200,China)

机构地区：[1]陕西省勉县医院检验科,陕西汉中724200

出　　处：《临床医学研究与实践》2025年第8期102-105,共4页Clinical Research and Practice

摘　　要：目的探讨急性心肌梗死患者的血清生长分化因子-15(GDF-15)、脂蛋白相关磷脂酶A_(2)(Lp-PLA_(2))、心型脂肪酸结合蛋白(H-FABP)水平与病情程度的相关性。方法选取2021年6月至2023年6月我科收治的100例急性心肌梗死患者作为观察组[根据冠脉病变支数分为单支(25例)、双支(40例)、三支(35例),并根据Killip分级分为Ⅰ级(34例)、Ⅱ级(25例)、Ⅲ级(29例)以及Ⅳ级(12例)];同期选取100名进行体检的健康者作为对照组。检测并比较各组的GDF-15、Lp-PLA_(2)、H-FABP水平,分析其与病情程度的相关性。结果观察组的血清GDF-15、Lp-PLA_(2)及H-FABP水平显著高于对照组(P<0.05)。双支、三支冠脉病变急性心肌梗死患者的血清GDF-15、Lp-PLA_(2)、H-FABP水平显著高于单支冠脉病变急性心肌梗死患者(P<0.05)。Ⅱ级、Ⅲ级、Ⅳ级急性心肌梗死患者的血清GDF-15、Lp-PLA_(2)、H-FABP水平显著高于Ⅰ级急性心肌梗死患者(P<0.05)。血清GDF-15、Lp-PLA_(2)、H-FABP与急性心肌梗死冠脉病变支数、Killip分级呈正相关(P<0.05)。结论血清GDF-15、Lp-PLA_(2)、H-FABP水平变化与急性心肌梗死患者病情程度密切相关,表达水平越高提示病情程度越严重,可作为急性心肌梗死病情程度的评估指标。Objective To investigate the correlation between serum growth differentiation factor-15(GDF-15),lipoprotein-associated phospholipase A_(2)(Lp-PLA_(2)),heart-type fatty acid-binding protein(H-FABP)levels and severity of acute myocardial infarction in patients.Methods A total of 100 patients with acute myocardial infarction admitted in our department from June 2021 to June 2023 were selected as the observation group[according to the number of coronary artery lesions,the patients were divided into single-vessel(25 cases),double-vessel(40 cases)and triple-vessel(35 cases);and according to Killip classification,the patients were divided into gradeⅠ(34 cases),gradeⅡ(25 cases),gradeⅢ(29 cases)and gradeⅣ(12 cases)];at the same time,100 healthy people underwent physical examiniation were selected as the control group.The levels of GDF-15,Lp-PLA_(2) and H-FABP in each group were detected and compared,and their correlation with the severity of the disease was analyzed.Results The levels of serum GDF-15,Lp-PLA_(2) and H-FABP in the observation group were significantly higher than those in the control group(P<0.05).The levels of serum GDF-15,Lp-PLA_(2) and H-FABP in patients with acute myocardial infarction with double-vessel and triple-vessel coronary artery disease were significantly higher than those in patients with acute myocardial infarction with single-vessel coronary artery disease(P<0.05).The levels of serum GDF-15,Lp-PLA_(2) and H-FABP in patients with gradeⅡ,gradeⅢand gradeⅣacute myocardial infarction were significantly higher than those in patients with gradeⅠacute myocardial infarction(P<0.05).The serum GDF-15,Lp-PLA_(2) and H-FABP were positively correlated with the number of coronary artery lesions and Killip grade in acute myocardial infarction(P<0.05).Conclusion The changes of serum GDF-15,Lp-PLA_(2) and H-FABP levels are closely related to the severity of acute myocardial infarction.The higher the expression level is,the more serious the disease is,which can be used as an evaluation index for

关 键 词：急性心肌梗死 生长分化因子-15 脂蛋白相关磷脂酶A2 心型脂肪酸结合蛋白 病情程度 

分 类 号：R541.6[医药卫生—心血管疾病]