老年女性糖化血红蛋白与盆腔炎性疾病严重程度的研究  

Study on Correlation Between Glycated Hemoglobin and Severity of Acute Pelvic Inflammatory Disease in Elderly Female Patients with Diabetes

作　　者：张慧 夏瑾燕[1] 叶岚 刘菊梅 龚玲 Zhang Hui;Xia Jinyan;YE Lan;LIU Ju-mei;GONG Ling(Huanggang Polytechnic College,Huanggang 438002 Hubei;Huanggang Central Hospital,Huanggang 438000 Hubei)

机构地区：[1]黄冈职业技术学院医药学院,湖北黄冈438002 [2]黄冈市中心医院,湖北黄冈438000

出　　处：《黄冈职业技术学院学报》2025年第1期84-88,共5页Journal of Huanggang Polytechnic

摘　　要：目的 研究老年女性糖尿病患者糖化血红蛋白水平与急性盆腔炎性疾病严重程度之间的相关性。方法 回顾性分析81例a PID的老年女性糖尿病患者资料,按病情严重程度分为轻度a PID组(51例)和重度aPID组(30例)。通过偏相关分析探讨HbA1c与炎症指标的关系,并用Logistic回归分析HbA1c对aPID严重程度的影响。结果 重度aPID组的HbA1c水平显著高于轻度组。偏相关分析结果显示,HbA1c水平分别与C反应蛋白、白细胞计数和中性粒细胞百分比呈正相关。多因素Logistic回归分析结果显示,校正混杂因素后,HbA1c是急性PID严重程度的独立危险因素。进一步的,依据四分位间距将HbA1c分为4个等级,回归分析显示更高的HbA1c水平与急性PID严重程度独立相关。结论 老年女性糖尿病中,高HbA1c水平与aPID严重程度独立相关。因此HbA1c或许有作为评估aPID严重程度的生物标志物的潜力。Objective To investigate the correlation between glycated hemoglobin(HbAlc)levels and the severity of acute pelvic inflammatory disease(aPID)in elderly female patients with diabetes.Methods A retrospective analysis was conducted on data from 81 elderly female patients with diabetes who had aPID.The patients were divided into a mild aPID group(51 cases)and a severe aPID group(30 cases)based on the severity of their condition.Partial correlation analysis was used to explore the relationship between HbAlc and inflammatory markers,and logistic regression analysis was performed to assess the impact of HbAlc on the severity of aPID.Results The HbAlc levels were significantly higher in the severe aPID group compared to the mild group.Partial correlation analysis revealed that HbA1c levels were positively correlated with C-reactive protein(r=0.468,P<0.001),white blood cell count(r=0.416,P<0.001),and neutrophil percentage(r=0.416,P<0.001).Multivariable logistic regression analysis showed that,after adjusting for confounding factors,HbAlc was an independent risk factor for the severity of acute PID(OR=1.397,95%CI:1.080-1.807,P=0.011).Furthermore,when HbAlc was categorized into four levels based on quartiles,regression analysis indicated that higher HbAlc levels were independently associated with the severity of acute PID(Level 3:OR=7.272,95%CI:1.246-42.462,P=0.027;Level 4:OR=13.150,95%CI:1.929-89.631,P=0.008).Conclusion In elderly female patients with diabetes,high HbAlc levels are independently associated with the severity of aPID.Therefore,HbAlc may have potential as a biomarker for assessing the severity of aPID.

关 键 词：急性盆腔炎性疾病 老年 糖化血红蛋白 严重程度 

分 类 号：R587.1[医药卫生—内分泌]