An asymmetric Janus membrane with anti-bacteria adhesion and rapid hemostasis properties for wound healing  

作　　者：Zihe Hu Gaoying Hong Mumian Chen Haiyan Wu Weiying Lu Yuewei Chen Zhijian Xie Changyu Shao Jue Shi 

机构地区：[1]Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province,Hangzhou 310000,China [2]State Key Laboratory of Fluid Power and Mechatronic Systems,School of Mechanical Engineering,Zhejiang University,Hangzhou 310027,China

出　　处：《Journal of Materials Science & Technology》2024年第25期201-214,共14页材料科学技术(英文版)

基　　金：funded by the National Natural Science Foun-dation of China(Grant No.81801024);the Key R&D project of the Zhejiang Science and Technology Department(Grant No.2021C03059).

摘　　要：Currently,commercial intraoral dressings have limitations as they only serve a single purpose and fail to meet various needs,such as hemostasis,wound protection,and dressing fixation.Here,we success-fully fabricated a multifunctional polycaprolactone-chitosan Janus membrane(PCJM)with simultaneous hydrophobic and hydrophilic properties.The hydrophobic layer consists of a dense and disordered poly-caprolactone,preventing bacterial adhesion,resisting fouling,and enhancing mechanical strength.The hydrophilic layer is a highly porous chitosan sponge,which facilitates cell and protein adhesion,as well as rapid absorption of blood and activation of the coagulation process.These results are confirmed by hemostasis experiments,which demonstrate that the PCJM had superior coagulation ability compared to commercial gelatin sponges and gauze,and by an early gingival healing model of beagle tooth extraction wounds,which exhibited excellent performance in promoting wound healing.Our work demonstrates the multifunctional PCJM wound dressing not only protects wounds from bacterial infections but also facili-tates rapid hemostasis and early healing of beagle gingival soft tissue,which holds significant potential for clinical translation and large-scale production.

关 键 词：Janus membrane ANTI-BACTERIA Rapid hemostasis Wound healing 

分 类 号：TB3[一般工业技术—材料科学与工程]