冬肾丸对于血液透析气阴两虚证患者营养状况的临床观察  

Clinical Observation of the Effect of Dongshen Pill on Nutritional Status in Patients with Qi and Yin Deficiency Syndrome Undergoing Hemodialysis

作　　者：杨丹丹 何泽云[1] YANG Dandan;HE Zeyun(Department of Nephrology,The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 522200,China)

机构地区：[1]湖南中医药大学第一附属医院肾内科,湖南长沙522200

出　　处：《中医药学报》2025年第3期97-102,共6页Acta Chinese Medicine and Pharmacology

基　　金：湖南省自然科学基金面上项目(2021JJ30522)。

摘　　要：目的:探讨冬肾丸改善血液透析气阴两虚型患者营养状况的作用。方法:选取2023年6月—2023年12月湖南中医药大学第一附属医院血液透析科收治的60例气阴两虚型患者,以随机数字表法分为对照组、观察组,每组30例,对照组给予基础营养支持,观察组在对照组基础上加服冬肾丸治疗,比较两组患者治疗前后的中医证候积分、营养指标、主观整体营养状况评定量表(PG-SGA)评分、血脂、生活质量量表(SF-36)评分的变化及治疗6个月的临床治疗效率。结果:治疗后两组中医证候积分、PG-SGA评分、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)均明显下降(P<0.05),观察组下降更明显(P<0.05);转铁蛋白(TRF)、人血白蛋白(ALB)、血红蛋白(Hb)、SF-36量表各维度评分、高密度脂蛋白胆固醇(HDL-C)均明显升高(P<0.05),观察组改善程度更明显(P<0.05);观察组疗效总有效率为93.33%(28/30),明显高于对照组73.33%(22/30)(P<0.05)。结论:冬肾丸可有助改善血液透析气阴两虚型患者的营养状况、调节血脂及提升生活质量。Objective:To investigate the effect of Dongshen Pill on improving the nutritional status of patients with Qi and Yin deficiency syndrome undergoing hemodialysis.Methods:A total of 60 patients receiving hemodialysis at The First Affiliated Hospital of Hunan University of Chinese Medicine from June 2023 to December 2023 were selected.The patients were randomly divided into two groups:the control group and the observation group,with 30 patients in each group.The control group received conventional basic nutritional support,while the observation group received the same in addition to Dongshen Pill.The changes in Traditional Chinese Medicine(TCM)syndrome scores,nutritional indicators,the Subjective Global Assessment(PG-SGA)score,blood lipids,and quality of life(SF-36)scores were compared before and after treatment,along with the clinical efficacy after 6 months of treatment.Results:After treatment,within-group comparisons showed that the TCM syndrome scores,transferrin(TRF),PG-SGA score,and low-density lipoprotein cholesterol(LDL-C)levels significantly decreased in both groups(P<0.05).Albumin(ALB),hemoglobin(Hb),SF-36 score in all dimensions,total cholesterol(TC),triglycerides(TG),and high-density lipoprotein cholesterol(HDL-C)levels significantly increased(P<0.05).The improvement was more pronounced in the observation group(P<0.05).The total effective rate in the observation group was 93.33%,which was significantly higher than the 73.33%in the control group(P<0.05).Conclusion:Dongshen Pill can help improve the nutritional status,regulate blood lipids,and enhance the quality of life in patients with Qi and Yin deficiency syndrome undergoing hemodialysis.

关 键 词：冬肾丸 血液透析 气阴两虚 血脂 生活质量 

分 类 号：R256.5[医药卫生—中医内科学]