乌药化学成分研究、质量标志物预测分析及其药理作用的研究进展  

Research Progress on the Chemical Constituents,Quality Marker Prediction,and Pharmacological Effects of Linderae Radix

作　　者：赵淑睿 李力恒[1,2] 张宇飞 李怡诺[1] 袁有才 王仁帅 高杰 ZHAO Shurui;LI Liheng;ZHANG Yufei;LI Yinuo;YUAN Youcai;WANG Renshuai;GAO Jie(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang Provincial Key Laboratory of Traditional Chinese Medicine Informatics,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江省中医药信息学重点实验室,黑龙江哈尔滨150040

出　　处：《中医药学报》2025年第3期103-111,共9页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金青年科学基金项目(81202638);黑龙江省博士后科研启动基金(LBH-Q18115);黑龙江省中医药科研项目(ZHY2024-012);黑龙江省“双一流”学科协同创新项目(LJGXCG2024-P35)。

摘　　要：乌药作为一种樟科山胡椒植物,其干燥块根自古以来便是药材,最早记载可追溯至《本草拾遗》,药用历史悠久。化学成分主要包括倍半萜、挥发油、黄酮、异喹啉生物碱等。本文通过对近10年相关文献资料进行广泛搜集与整理,从质量传递追溯、传统药性理论、化学成分的可检测性及药理作用等维度,对乌药的质量标志物进行科学的预测与分析,将乌药中波尔定碱、植物甾醇、五羟黄酮、去甲异波尔定、异乌药内酯、乌药醚内酯等纳入乌药质量标志物的考虑范畴。在深入剖析乌药化学成分、质量标志物的基础上,可知乌药具有抗炎镇痛、抗肿瘤、抗氧化、调节心血管系统、防治糖尿病及肾病、保肝等广泛作用,为全面了解乌药的开发现状及二次开发提供参考。Linderae Radix,derived from the dried rhizome of Lindera angustifolia,a member of the Lauraceae family,has a long history of medicinal use,with its earliest record in the Supplement to the Materia Medica(Bencao Shiyi).The main chemical constituents of Linderae Radix include furan sesquiterpenoids and their lactones,essential oils,flavonoids,and isoquinoline alkaloids.This article collects and organizes relevant literature from the past 10 years to predict and analyze quality markers for Linderae Radix from multiple dimensions,including quality traceability,traditional medicinal theories,chemical detectability,and pharmacological actions.Based on scientific predictions,alkaloids like boldine,plant sterols,pentahydroxyflavone,dehydroiso-boldine,iso-lindera lactones,and lignan lactones have been identified as potential quality markers for Linderae Radix.Through a deep analysis of Linderae Radixs chemical constituents and quality markers,the herb is shown to possess a wide range of pharmacological effects,including anti-inflammatory and analgesic actions,anticancer,antioxidant properties,cardiovascular system regulation,prevention and treatment of diabetic nephropathy,and hepatoprotection.These findings provide a reference for understanding the current development and potential secondary development of Linderae Radix.

关 键 词：乌药 化学成分 质量标志物 药理作用 研究进展 

分 类 号：R285[医药卫生—中药学]