血管化骨类器官修复早期股骨头缺血性坏死策略  

Strategy for repairing early-stage avascular necrosis of femoral head using vascularized bone organoids

作　　者：王健 白龙[2] 陈晓 苏佳灿 WANG Jian;BAI Long;CHEN Xiao;SU Jiacan(Department of Orthopaedics,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Institute of Translational Medicine,Shanghai University,Shanghai 200444,China)

机构地区：[1]上海交通大学医学院附属新华医院骨科,上海200092 [2]上海大学转化医学研究院,上海200444

出　　处：《中华骨与关节外科杂志》2025年第3期193-199,共7页Chinese Journal of Bone and Joint Surgery

基　　金：国家自然科学基金(82230071);上海申康医院发展中心研究型医师创新转化能力培训项目(SHDC2023CRT013);上海市创新医疗器械应用示范项目(23SHS05700-01)。

摘　　要：股骨头缺血性坏死(ANFH)是由于血供不足导致股骨头骨组织死亡的疾病,会引起髋关节疼痛和功能障碍,严重损害患者运动功能。ANFH的病理生理包括血供不足导致的骨细胞缺氧、骨代谢失衡、细胞凋亡及炎症反应,早期基本无症状,晚期常表现为关节功能严重受损。目前,ANFH采取保守治疗和手术干预均存在局限性,如效果不佳和复发风险等。血管化骨类器官作为一种新兴治疗手段,模拟股骨头微环境,增强血管生成,促进骨细胞再生,从而有效应对早期ANFH,是更具针对性的干预方案。为进一步推动血管化骨类器官技术发展和临床转化研究,本文就ANFH治疗面临的挑战、血管化骨类器官构建策略以及血管化骨类器官在ANFH修复中的应用潜力进行阐述,以期为相关领域的科研和临床工作者提供参考和启发,加速这一新兴技术的创新突破和转化应用,从而造福更多早期ANFH患者。Avascular necrosis of femoral head(ANFH)refers to the death of bone tissue in the femoral head due to insufficient blood supply,leading to hip joint pain and dysfunction,severely impairing patients'mobility.The pathophysiology of ANFH includes osteocyte hypoxia caused by insufficient blood supply,imbalance of bone metabolism,apoptosis,and inflammatory response.It is asymptomatic in the early stage,and often manifests as severe joint function impairment in the late stage.Currently,both conservative treatments and surgical interventions for ANFH have limitations,such as poor efficacy and risk of recurrence.As an emerging therapeutic approach,vascularized bone organoid technology simulates the microenvironment of the femoral head,enhances angiogenesis,and promotes osteocyte regeneration,thereby effectively addressing early-stage ANFH and offering a more targeted intervention strategy.To further advance the development of vascularized bone organoid technology and drive its clinical translational research,this article discusses the challenges in ANFH treatment,the construction strategies of vascularized bone organoids,and the potential applications of this technology in ANFH repair.It aims to provide references and inspiration for researchers and clinicians in related fields,accelerating innovative breakthroughs and translational applications of vascularized bone organoid technology to ultimately benefit more patients with ANFH.

关 键 词：股骨头缺血性坏死 血管化 骨类器官 

分 类 号：R318[医药卫生—生物医学工程]