针刺联合高压氧治疗创伤后认知功能障碍的临床观察  

Clinical observation of acupuncture combined with hyperbaric oxygen in the treatment of post-traumatic cognitive dysfunction

作　　者：王纯纯 孙文超 潘昊 费智敏[1] WANG Chunchun;SUN Wenchao;PAN Hao;FEI Zhimin(Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《上海针灸杂志》2025年第3期326-330,共5页Shanghai Journal of Acupuncture and Moxibustion

摘　　要：目的观察针刺联合高压氧治疗创伤后认知功能障碍的临床疗效。方法将74例脑创伤术后认知功能障碍患者按随机数字表法分为对照组和试验组,每组37例。两组均予常规治疗,对照组应用高压氧治疗,试验组采用针刺联合高压氧治疗。比较两组治疗前后Glasgow预后扩展量表(extended Glasgow outcome scale,EGOS)、Barthel指数(Barthel index,BI)、简易精神状态检查(mini-mental state examination,MMSE)和功能独立性量表(functionalindependencemeasure,FIM)评分及检测患者血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)和胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)水平。结果两组治疗后EGOS和BI评分均升高,差异有统计学意义(P<0.05);试验组治疗后EGOS和BI评分高于对照组,差异有统计学意义(P<0.05)。两组治疗后MMSE和FIM评分均升高,差异有统计学意义(P<0.05);试验组治疗后MMSE和FIM评分高于对照组,差异有统计学意义(P<0.05)。两组治疗后血清BDNF水平升高、GFAP水平降低,差异有统计学意义(P<0.05);试验组治疗后血清BDNF水平高于对照组,GFAP水平低于对照组,差异有统计学意义(P<0.05)。结论在常规治疗基础上,针刺联合高压氧可明显提高对创伤后患者的认知能力,改善生存质量,能有效改善相关细胞因子的表达,临床疗效显著。Objective To observe the clinical efficacy of acupuncture combined with hyperbaric oxygen in the treatment of post-traumatic cognitive dysfunction.Method Seventy-four patients with postoperative cognitive dysfunction after traumatic brain injury were divided into a control group and a trial group according to the random number table method,with 37 patients in each group.Both groups were treated with conventional therapy,while the control group was treated with hyperbaric oxygen therapy and the trial group was treated with acupuncture combined with hyperbaric oxygen therapy.Comparison of extended Glasgow outcome scale(EGOS),Barthel index(BI),mini-mental state examination(MMSE),functional independence measure(FIM),serum brain-derived neurotrophic factor(BDNF)and glial fibrillary acidic protein(GFAP)levels were performed in the two groups before and after treatment.Result The EGOS and BI scores of both groups increased after treatment,and the differences were statistically significant(P<0.05);the EGOS and BI scores of the trial group were higher than those of the control group,and the differences were statistically significant(P<0.05).The MMSE and FIM scores increased in both groups after treatment,and the difference was statistically significant(P<0.05);the MMSE and FIM scores were higher in the trial group than in the control group after treatment,and the difference was statistically significant(P<0.05).The serum BDNF level increased and GFAP level decreased in both groups after treatment,and the difference was statistically significant(P<0.05);the serum BDNF level in the trial group was higher than that of the control group,and GFAP level in the trial group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion On the basis of conventional treatment,acupuncture combined with hyperbaric oxygen can significantly improve the cognitive ability of post-traumatic patients,improve the quality of survival,can effectively improve the expression of relevant cytokines,th

关 键 词：针刺疗法 针药并用 高压氧 脑损伤 创伤性 认知障碍 

分 类 号：R246.6[医药卫生—针灸推拿学]