电针联合宫腔灌注对薄型子宫内膜胚胎移植妊娠结局和焦虑状态的影响  

Effect of electroacupuncture combined with intrauterine infusion on pregnancy outcome and anxiety state of embryo transfer with thin endometrium

作　　者：许婷 曹华斌[1] 庄元[1] XU Ting;CAO Huabin;ZHUANG Yuan(Jiangxi Maternal and Child Health Hospital,Nanchang 330006,China)

机构地区：[1]江西省妇幼保健院,南昌330006

出　　处：《上海针灸杂志》2025年第3期331-336,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：江西省中医药管理局科技计划课题(2022A211);江西省卫生健康委科技计划课题(202211101)。

摘　　要：目的观察电针联合宫腔灌注粒细胞集落刺激因子(granulocyte-stimulating factor,G-CSF)对冻融胚胎移植(frozen-thawed embryo transfer,FET)的薄型子宫内膜患者胚胎移植妊娠结局和焦虑状态的影响。方法将102例行FET的薄型子宫内膜患者,随机分为研究组(54例)和对照组(48例)。研究组采用电针治疗联合G-CSF宫腔灌注治疗,对照组采用G-CSF宫腔灌注治疗。比较两组治疗前后的子宫内膜厚度、形态、血流动力学参数和汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分,并随访胚胎着床率、临床妊娠率和早期流产率。结果两组治疗后子宫内膜厚度较治疗前增加,且研究组高于对照组,差异有统计学意义(P<0.05)。研究组治疗后A型子宫内膜比例高于对照组,差异有统计学意义(P<0.05)。两组治疗后阻力指数(resistance index,RI)较治疗前降低,且研究组低于对照组,差异有统计学意义(P<0.05);两组治疗后血管化指数(vascularization index,VI)、血流指数(flow index,FI)和血管化血流指数(vascularization blood flow index,VFI)较治疗前升高,且研究组高于对照组,差异有统计学意义(P<0.05)。两组治疗后HAMA评分较治疗前降低,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组的胚胎着床率和临床妊娠率高于对照组,差异有统计学意义(P<0.05),而早期流产率有下降趋势,但差异无统计学意义(P>0.05)。结论电针联合G-CSF宫腔灌注可提高行FET的薄型子宫内膜患者的胚胎着床率和临床妊娠率,缓解焦虑情绪,效果优于单用G-CSF。Objective To observe the effects of electroacupuncture combined with intrauterine infusion of granulocyte-colony stimulating factor(G-CSF)on pregnancy outcome and anxiety state of patients with thin endometrium undergoing frozen-thawed embryo transfer(FET).Method A total of 102 patients with thin endometrium who underwent FET were randomly divided into a study group(54 cases)and a control group(48 cases).The study group was treated with electroacupuncture therapy combined with G-CSF intrauterine infusion,and the control group was treated with G-CSF intrauterine infusion.The endometrial thickness,morphology,hemodynamic parameters and Hamilton anxiety scale(HAMA)scores of the two groups were compared before and after treatment,and the embryo implantation rate,clinical pregnancy rate and early miscarriage rate were followed up.Result After treatment,the endometrial thickness of both groups were higher than those before treatment,and that of the study group was higher than that of the control group,and the differences were statistically significant(P<0.05).After treatment,the proportion of type A endometrium in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the resistance index(RI)of both groups were lower than those before treatment,and that of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the vascularization index(VI),flow index(FI)and vascularization blood flow index(VFI)of both groups were higher than those before treatment,and those of the study group were higher than those of the control group,and the difference was statistically significant(P<0.05).The HAMA scores of both groups were lower than those before treatment,and those of the study group were lower than those of the control group,and the difference was statistically significant(P<0.05).The embryo implantation rate and clinical pregnancy rate of the study group were higher than those of t

关 键 词：电针 宫腔灌注 辅助生殖技术 不孕症 不育 女性 子宫内膜容受性 血液流变学 

分 类 号：R246.3[医药卫生—针灸推拿学]