生长抑素在重症急性胰腺炎治疗中的应用对胃肠道功能恢复及炎症反应的影响  

The impact of somatostatin application in the treatment of severe acute pancreatitis on gastrointestinal function recovery and inflammatory response

作　　者：谢明娇 蔡筱颖 李娜 徐足 陈俊杰 Xie Mingjiao;Cai Xiaoying;Li Na;Xu Zu;Chen Junjie(Kunming Second People's Hospital,Kunming,Yunnan 650000,China)

机构地区：[1]昆明市第二人民医院,云南昆明650000

出　　处：《首都食品与医药》2025年第5期70-73,共4页Capital Food Medicine

摘　　要：目的评估生长抑素(Somatostatin,SST)在重症急性胰腺炎(Severe Acute Pancreatitis,SAP)患者治疗中的应用对胃肠道功能恢复及炎症反应的影响.方法收集2023年1月-2023年12月收治的SAP患者120例,采用随机数表法分为对照组(60例,给予常规治疗方案)和实验组(60例,在对照组基础上追加SST静脉滴注治疗).比较两组治疗后血清炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]、腹痛缓解时间、住院时间、胃肠道功能恢复情况以及生化指标(AMS、ET、DAO)的变化.结果治疗后,实验组炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]均低于对照组(P<0.05);实验组腹痛缓解时间、住院时间均短于对照组(P<0.05);实验组胃肠道功能恢复时间(肠鸣音恢复时间、肛门排气时间、血清淀粉酶恢复时间)均短于对照组(P<0.05);实验组生化指标(AMS、ET、DAO)均低于对照组(P<0.05).结论SST静脉滴注可促进SAP患者胃肠道功能恢复,保护肠黏膜,并减轻炎症反应.Objective To evaluate the effect of somatostatin(SST)application in the treatment of patients with severe acute pancreatitis(SAP)on gastrointestinal function recovery and inflammatory response.Methods A total of 120 patients with severe acute pancreatitis(SAP)admitted from January 2023 to December 2023 were collected and randomly assigned using a digital random table method into a control group(60 cases,receiving standard treatment)and an experimental group[60 cases,receiving intravenous somatostatin(SST)in addition to the standard treatment].The levels of serum inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-8(IL-8),tumor necrosis factor-alpha(TNF-α)],time to abdominal pain relief,length of hospital stay,gastrointestinal function recovery,and changes in biochemical markers(AMS,ET,DAO)were compared between the two groups after treatment.Results After treatment,the inflammatory factors in the experimental group[high-sensitivity C-reactive protein(hs-CRP),interleukin-8(IL-8),and tumor necrosis factor-alpha(TNF-α)]were significantly lower than those in the control group(P<0.05).The time to abdominal pain relief and length of hospital stay in the experimental group were both shorter than in the control group(P<0.05).Additionally,the recovery of gastrointestinal function(time to return of bowel sounds,time to pass gas,and time for serum amylase to return to normal)in the experimental group was shorter than that in the control group(P<0.05).Furthermore,the biochemical markers(AMS,ET,DAO)in the experimental group were lower than those in the control group(P<0.05).Conclusion Intravenous administration of somatostatin(SST)can promote gastrointestinal function recovery in patients with severe acute pancreatitis(SAP),protect intestinal mucosal,and reduce inflammatory response.

关 键 词：重症急性胰腺炎 生长抑素 炎症因子 胃肠道功能恢复 

分 类 号：R657.5[医药卫生—外科学]