硫酸氨基葡萄糖联合依托考昔及关节镜下清理术对膝骨关节炎患者疼痛及膝关节功能的影响  

Effect of glucosamine sulfate combined with etoricoxib and arthroscopic debridement on pain and knee function in patients with knee osteoarthritis

作　　者：庄金岩 刘中岳 王朋飞 ZHUANG Jinyan;LIU Zhongyue;WANG Pengfei(Department of Arthroplasty,Xuchang Renhe Bone hospital,Xuchang Henan 461000,China)

机构地区：[1]许昌仁和骨伤医院关节科,河南许昌461000

出　　处：《天津药学》2025年第2期182-185,共4页Tianjin Pharmacy

摘　　要：目的探讨硫酸氨基葡萄糖联合依托考昔及关节镜下清理术在膝骨关节炎(KOA)患者中的应用价值。方法选取2023年8月至2024年8月许昌仁和骨伤医院收治的80例KOA患者,以随机数字表法分为两组,各40例。对照组采用关节镜下清理术及依托考昔治疗,观察组采用硫酸氨基葡萄糖联合依托考昔及关节镜下清理术治疗。对比两组疗效、治疗前后炎症因子水平、疼痛程度[视觉模拟评分法(VAS)评分]、膝关节功能[美国膝关节协会评分法(KSS)评分]及治疗期间的不良反应发生情况。结果观察组治疗总有效率(95.00%)高于对照组(77.50%)(P<0.05)。治疗后观察组肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)、IL-1β水平较对照组更低(P<0.05)。治疗后2、4、8周,观察组VAS评分较对照组更低(P<0.05)。治疗后观察组临床、功能评价KSS评分较对照组更高(P<0.05);两组不良反应发生率对比无统计学差异(P>0.05)。结论硫酸氨基葡萄糖联合依托考昔及关节镜下清理术治疗KOA在提高治疗总有效率、降低炎症因子水平、缓解疼痛、改善膝关节功能方面效果突出,且安全性良好。Objective To explore the application value of glucosamine sulfate combined with etoricoxib and arthroscopic debridement in patients with knee osteoarthritis(KOA).Methods A total of 80 patients with KOA admitted to Xuchang Renhe Bone Hospital from August 2023 to August 2024 were taken as the subjects.All cases were assigned to two groups according to random number table,with 40 cases in each group.The patients of control group underwent arthroscopic debridement and etoricoxib,and on this basis,the patients of observation group added glucosamine sulfate.The comparisons were performed on curative effect,levels of inflammatory factors before and after treatment,the degree of pain[visual analogue scale(VAS)score],knee function[American Knee Society Score(KSS)]and the occurrence of adverse reactions during treatment in both groups.Results The observation group achieved higher total effective rate than the control group(95.00%vs 77.50%).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-17(IL-17),IL-1βin the observation group were lower than those in the control group(P<0.05).After 2,4,and 8 weeks of treatment,the VAS scores in the observation group were lower than those in the control group(P<0.05).After treatment,the KSS scores for clinical and functional evaluation in the observation group were higher than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of glucosamine sulfate,etoricoxib and arthroscopic debridement in the treatment of KOA has outstanding effects in improving the total effective rate,reducing the levels of inflammatory factors,relieving pain,and improving knee function,which has good safety.

关 键 词：膝骨关节炎 硫酸氨基葡萄糖 依托考昔 关节镜下清理术 膝关节功能 

分 类 号：R684[医药卫生—骨科学]