青荷饮治疗慢性咽炎临床观察  

Clinical Observation on Qinghe Decoction in the Treatment of Chronic Pharyngitis

作　　者：俞菲菲 高燕 盛国荣 范博义 YU Feifei;GAO Yan;SHENG Guorong;FAN Boyi(Nantong Hanyao Traditional Chinese Medicine Hospital,Nantong,Jiangsu,China 226001;School of Pharmacy,Nantong University,Nantong,Jiangsu,China 226001)

机构地区：[1]南通汉药中医医院,江苏南通226001 [2]南通大学药学院,江苏南通226001

出　　处：《中国药业》2025年第6期81-85,共5页China Pharmaceuticals

基　　金：江苏省南通市基础科学研究和社会民生科技计划项目[MSZ2022102]。

摘　　要：目的探讨青荷饮治疗慢性咽炎的临床疗效。方法选取南通汉药中医医院2022年1月至2023年6月收治的慢性咽炎患者112例,采用随机数字表奇偶法分为观察组(58例,服用青荷饮)和对照组(54例,服用蒲地蓝消炎口服液),两组均治疗3个疗程(每疗程7 d)。结果与治疗前比较,治疗1,2,3周后两组患者中医症状积分(除对照组患者治疗1周的咽痒、咽痛、异物症状评分及治疗1,2周的黏膜充血症状评分无明显变化外)均明显降低,C反应蛋白(CRP)、CD_(8)^(+)水平明显降低,血管内皮细胞黏附分子-1(VCAM-1)、血清表皮生长因子(EGF)、分泌性免疫球蛋白A(sIgA)、CD_(4)^(+)水平和CD_(4)^(+)/CD_(8)^(+)明显升高,且观察组患者(除治疗1周后的咽痒、黏膜充血症状积分及sIgA、CD_(4)^(+)、CD_(8)^(+)水平和CD_(4)^(+)/CD_(8)^(+))变化幅度明显大于对照组。观察组患者治疗2,3周后的总有效率分别为72.41%和93.10%,明显高于对照组的53.70%和79.63%(P<0.05);观察组复发率为12.96%,明显低于对照组的32.56%(P<0.05)。结论青荷饮治疗慢性咽炎,短期内复发率低,其作用机制可能与调节患者细胞免疫功能有关。Objective To investigate the clinical efficacy of Qinghe Decoction in the treatment of chronic pharyngitis.Methods A total of 112 patients with chronic pharyngitis admitted to Nantong Hanyao Traditional Chinese Medicine Hospital from January 2022 to June 2023 were randomly divided into an observation group(58 cases,treated with Qinghe Decoction)and a control group(54 cases,treated with Pudilan Xiaoyan Oral Liquid)using an odd-even random number table method.Both groups were treated for three courses(7 days per course).Results Compared with before treatment,the traditional Chinese medicine(TCM)symptom scores of both groups significantly decreased after 1,2,and 3 weeks of treatment,except for the itching,pain,and foreign body sensation scores at week 1 in the control group,as well as the mucosal congestion score at weeks 1 and 2,which showed no significant change.Levels of C-reactive protein(CRP)and CD_(8)^(+)significantly decreased,while vascular cell adhesion molecule-1(VCAM-1),serum epidermal growth factor(EGF),secretory immunoglobulin A(sIgA),CD_(4)^(+),and the CD_(4)^(+)/CD_(8)^(+)ratio significantly increased.The magnitude of these changes in the observation group was significantly greater than in the control group,except for the itching and mucosal congestion scores,as well as the levels of sIgA,CD_(4)^(+),CD_(8)^(+),and the CD_(4)^(+)/CD_(8)^(+)ratio at week 1.The total effective rates at weeks 2 and 3 were 72.41%and 93.10%in the observation group,respectively,significantly higher than the 53.70%and 79.63%in the control group(P<0.05).The recurrence rate in the observation group was 12.96%,significantly lower than the 32.56%in the control group(P<0.05).Conclusion Qinghe Decoction has a low short-term recurrence rate in the treatment of chronic pharyngitis,and its mechanism of action may be related to the regulation of cellular immune function.

关 键 词：慢性咽炎 青荷饮 中医症状积分 临床疗效 炎性因子 免疫功能 

分 类 号：R969.4[医药卫生—药理学]