S-乙酰-L-谷胱甘肽的药理作用与应用探讨  

Pharmacological Effects and Applications of S-Acetyl-L-Glutathione

作　　者：杨欣[1,2] 郑阳 李天泉 李頔 YANG Xin;ZHENG Yang;LI Tianquan;LI Di(The Second Affiliated Hospital of Chongqing Medical University,Chongqing,China 400010;School of Pharmacy,Chongqing Medical University,Chongqing,China 400016;Chongqing Kangzhou Big DataCo.,Ltd.,Chongqing,China 401336)

机构地区：[1]重庆医科大学附属第二医院,重庆400010 [2]重庆医科大学药学院,重庆400016 [3]重庆康洲大数据<集团>有限公司,重庆401336

出　　处：《中国药业》2025年第6期128-128,I0001-I0004,共5页China Pharmaceuticals

基　　金：重庆市“博士后研究项目特别资助”项目[X2-1064];重庆市中青年医学高端人才项目。

摘　　要：目的为S-乙酰-L-谷胱甘肽(SAG)的进一步研发和应用提供参考。方法分析SAG的药物代谢动力学(PK)/药物效应动力学(PD)特性、药理作用、临床及其他领域的应用,并探讨其应用前景。结果相比谷胱甘肽及其他谷胱甘肽衍生物,SAG稳定性好、起效快、生物利用度高、安全性高。SAG具有抗氧化应激、清除自由基、抑制铁死亡等多种药理作用。SAG在肝病、急性肾损伤、阿尔茨海默病、帕金森病、免疫调节、急性胰腺炎、糖尿病、病毒感染、囊性纤维化、慢性阻塞性肺疾病等临床领域,以及食品保健、皮肤美容、动物医疗等其他领域的应用均有数据支持。结论与谷胱甘肽及其他谷胱甘肽衍生物相比,SAG更有药理学优势,且在临床医疗和其他领域显示出一定的研发与应用价值。Objective To provide a reference for the further development and application of S-acetyl-L-glutathione(SAG).Methods The pharmacokinetics(PK)/pharmacodynamics(PD)characteristics,pharmacological effects,clinical applications,and other potential uses of SAG were analyzed,and its application prospects were discussed.Results Compared with glutathione and other glutathione derivatives,SAG exhibits better stability,faster onset of action,higher bioavailability,and superior safety.SAG possesses multiple pharmacological effects,including antioxidant stress reduction,free radical scavenging,and ferroptosis inhibition.It has documented applications in various clinical conditions such as liver diseases,acute kidney injury,Alzheimer's disease,Parkinson's disease,immune regulation,acute pancreatitis,diabetes,viral infections,cystic fibrosis,and chronic obstructive pulmonary disease.Additionally,SAG is supported by data for its use in food supplements,skincare,and veterinary medicine.Conclusion Compared to glutathione and its derivatives,SAG demonstrates superior pharmacological advantages and holds promising value for further research and application in clinical and other fields.

关 键 词：S-乙酰-L-谷胱甘肽 药理作用 抗氧化剂 谷胱甘肽 肝损伤 活性氧 

分 类 号：R965[医药卫生—药理学]